(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

Product Name: (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
CAS No.: 1168150-46-6
Chemical Name: (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Synonyms: (3E)-2;Nintedanib-017;BIBF1120 Intermediate4;Nintedanib impurities3;Nintedanib Impurity 125;Nintedanib Intermediate 4;Nintedanib ethanesulfonate intermediates;oxo-1h-indole-6-carboxylic acid methyl ester;3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...;methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CBNumber: CB92671010
Molecular Formula: C18H15NO4
Formula Weight: 309.32
MOL File: 1168150-46-6.mol

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(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Property

Boiling point:: 523.8±50.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.62±0.20(Predicted)
form: Solid
color: Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M322025
Product name: (E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging: 100mg
Price: $110
Updated: 2021/12/16

TRC

Product number: M322025
Product name: (E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging: 250mg
Price: $225
Updated: 2021/12/16

TRC

Product number: M322025
Product name: (E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging: 500mg
Price: $425
Updated: 2021/12/16

TRC

Product number: M322025
Product name: (E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging: 1g
Price: $795
Updated: 2021/12/16

AK Scientific

Product number: 0001AP
Product name: Methyl(3E)-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate
Packaging: 25mg
Price: $39
Updated: 2021/12/16

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(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Suppliers

China 138 India 6 United Kingdom 1 United States 4 Global 149

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
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Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

S.Z. PhyStandard Bio-Tech. Co., Ltd.

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Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
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Shanghai Topbiochem Technology Co., Ltd

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Email: info@topbiochem.com
Country: China
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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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Country: China
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TargetMol Chemicals Inc.

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Fax: 021-33632979
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Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
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Chengdu Climb Pharmaceutical Technology Co., Ltd.

Tel: 028-87608726 13540107218
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Jinan XuanDe Chemical Co., Ltd.

Tel: 0531-88803958; 18866891188
Fax: 0531-82777287
Email: zhaojiangxia@shiningpharm.com
Country: China
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ChemStrong Scientific Co.,Ltd

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Shanghai SE Pharm Co., Ltd

Tel: 18112588827
Email: sales4@sepharm.com.cn
Country: China
ProdList: 300
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View Lastest Price from (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester manufacturers

Nanjing Fred Technology Co., Ltd

Product: (E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1168150-46-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-19

Henan Aochuang Chemical Co.,Ltd.

Product: (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 1168150-46-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1168150-46-6
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-13

1168150-46-6, (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl esterRelated Search:

Methyl 2-oxoindole-6-carboxylate 1-Chloro-4-(trimethoxymethyl)benzene Methyl 1-acetyl-2-oxoindoline-6-carboxylate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide BIBF 1202 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Avibactam sodium Nintedanib 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Avibactam INT 1 BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Nintedanib Ethanesulfonate Salt 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

BIBF1120 Intermediate4

Nintedanib ethanesulfonate intermediates

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este

methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-

Nintedanib Intermediate 4

(3E)-2

3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

Nintedanib-017

oxo-1h-indole-6-carboxylic acid methyl ester

Nintedanib Impurity 125

3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...

Nintedanib impurities3

1168150-46-6