ChemicalBook > CAS DataBase List > (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

Product Name
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
CAS No.
1168150-46-6
Chemical Name
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Synonyms
(3E)-2;Nintedanib-017;BIBF1120 Intermediate4;Nintedanib impurities3;Nintedanib Impurity 125;Nintedanib Intermediate 4;Nintedanib ethanesulfonate intermediates;oxo-1h-indole-6-carboxylic acid methyl ester;3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...;methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CBNumber
CB92671010
Molecular Formula
C18H15NO4
Formula Weight
309.32
MOL File
1168150-46-6.mol
More
Less

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Property

Boiling point:
523.8±50.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
10.62±0.20(Predicted)
form 
Solid
color 
Light Yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M322025
Product name
(E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging
100mg
Price
$110
Updated
2021/12/16
TRC
Product number
M322025
Product name
(E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging
250mg
Price
$225
Updated
2021/12/16
TRC
Product number
M322025
Product name
(E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging
500mg
Price
$425
Updated
2021/12/16
TRC
Product number
M322025
Product name
(E)-Methyl3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging
1g
Price
$795
Updated
2021/12/16
AK Scientific
Product number
0001AP
Product name
Methyl(3E)-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate
Packaging
25mg
Price
$39
Updated
2021/12/16
More
Less

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Suppliers

China 129 India 6 United Kingdom 1 United States 4 Global 140
More
Less

View Lastest Price from (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester manufacturers

Nanjing Fred Technology Co., Ltd
Product
(E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1168150-46-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-19
Henan Aochuang Chemical Co.,Ltd.
Product
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 1168150-46-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1168150-46-6
Price
US $100.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
98%
Supply Ability
10KG
Release date
2021-09-13

1168150-46-6, (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl esterRelated Search:

Methyl 2-oxoindole-6-carboxylate 1-Chloro-4-(trimethoxymethyl)benzene Methyl 1-acetyl-2-oxoindoline-6-carboxylate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide BIBF 1202 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Avibactam sodium Nintedanib 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Avibactam INT 1 BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Nintedanib Ethanesulfonate Salt 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide

  • (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
  • BIBF1120 Intermediate4
  • Nintedanib ethanesulfonate intermediates
  • (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este
  • methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-
  • Nintedanib Intermediate 4
  • (3E)-2
  • 3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
  • Nintedanib-017
  • oxo-1h-indole-6-carboxylic acid methyl ester
  • Nintedanib Impurity 125
  • 3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...
  • Nintedanib impurities3
  • 1168150-46-6