(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

Product Name: (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS No.: 1987887-92-2
Chemical Name: (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Synonyms: Nintedanib-011;Intedanib Impurity D;Nintedanib Impurity q;Nintedanib Impurity 34;Nintedanib impuritiesD;Nintedanib Impurity N4;Nintedanib impurities25;NintedanibN-Methylimpurity;Nintedanib N-Methyl Aniline Analog;Nintedanib Impurity 71 (Intedanib Impurity 71)
CBNumber: CB13335038
Molecular Formula: C24H21N3O3
Formula Weight: 399.44
MOL File: 1987887-92-2.mol

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(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Property

Melting point:: 273 - 276°C
Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.316±0.06 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.16±0.20(Predicted)
form: Solid
color: Yellow to Orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D492443
Product name: (3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylicAcidMethylEster
Packaging: 5mg
Price: $255
Updated: 2021/12/16

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(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties,Usage,Production

Uses

(3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester is an impurity of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Suppliers

China 47 India 4 United States 4 Global 55

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1987887-92-2, (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylateRelated Search:

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Nintedanib Methyl oxindole-5-carboxylate N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER Methyl 1-acetyl-2-oxoindoline-6-carboxylate 1-Chloro-4-(trimethoxymethyl)benzene METHYL OXINDOLE-7-CARBOXYLATE P-ANISALDEHYDE DIMETHYL ACETAL 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate BIBF 1202 N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide Methyl 4-chloro-3-nitrobenzoate

Intedanib Impurity D

Nintedanib Impurity 34

Nintedanib-011

Nintedanib impurity 10/(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)meth...

1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-

Nintedanib Impurity q

(3Z)?-2,?3-Dihydro-?3-?[[[4-?(methylamino)?phenyl]?amino]?phenylmethylene]?-?2-?oxo-?1H-?Indole-?6-?carboxylic Acid Methyl Ester

(Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (Nintedanib Impurity)

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylen...

Nintedanib impurities25

Nintedanib impuritiesD

NintedanibN-Methylimpurity

Nintedanib N-Methyl Aniline Analog

(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

Nintedanib Impurity N4

Nintedanib Impurity 71 (Intedanib Impurity 71)

Methyl (3Z)-2,3-Dihydro-3-[[[4-(methylamino)phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylate

1987887-92-2

1105067-87-6

221624-94-9