1-Ethylpiperazine

Product Name: 1-Ethylpiperazine
CAS No.: 5308-25-8
Chemical Name: 1-Ethylpiperazine
Synonyms: N-ETHYLPIPERAZINE;NEPRZ;1-Ethylperazine;N-Ethylpiperazin;AKOS BBS-00003610;1-ETHYLPIPERAZINE;ETHYLPIPERAZINE-N;1-ethyl-piperazin;1-ethvlpiperazine;N-Alkylpiperazine
CBNumber: CB6384137
Molecular Formula: C6H14N2
Formula Weight: 114.19
MOL File: 5308-25-8.mol

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1-Ethylpiperazine Property

Melting point:: -60 °C
Boiling point:: 157 °C(lit.)
Density: 0.899 g/mL at 25 °C(lit.)
vapor pressure: 2.48hPa at 20℃
refractive index: n20/D 1.469(lit.)
Flash point:: 110 °F
storage temp.: 2-8°C
solubility: soluble
form: Liquid
pka: 9.27±0.10(Predicted)
Specific Gravity: 0.899
color: Clear colorless to yellow
Water Solubility: soluble
Sensitive: Air Sensitive
BRN: 102971
InChI: 1S/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3
InChIKey: WGCYRFWNGRMRJA-UHFFFAOYSA-N
SMILES: CCN1CCNCC1
LogP: -0.1 at 20℃
CAS DataBase Reference: 5308-25-8(CAS DataBase Reference)
NIST Chemistry Reference: N-ethylpiperazine(5308-25-8)
EPA Substance Registry System: Piperazine, 1-ethyl- (5308-25-8)

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Safety

Hazard Codes: Xi,Hazard
Risk Statements: 36/37/38-10
Safety Statements: 26-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 1
RTECS: TM0815500
F: 10-34
HazardClass: 3
PackingGroup: III
HS Code: 29335995
Storage Class: 3 - Flammable liquids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1B
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1266802
Product name: 1-Ethylpiperazine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 0.5ml
Price: $1760
Updated: 2025/07/31

Sigma-Aldrich

Product number: 415308
Product name: 1-Ethylpiperazine
Purity: 98%
Packaging: 50ml
Price: $48
Updated: 2024/03/01

TCI Chemical

Product number: E0355
Product name: 1-Ethylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: E0355
Product name: 1-Ethylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 100mL
Price: $46
Updated: 2025/07/31

Sigma-Aldrich

Product number: 415308
Product name: 1-Ethylpiperazine
Purity: 98%
Packaging: 250ml
Price: $145
Updated: 2024/03/01

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1-Ethylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellow liquid

Uses

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

Uses

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammability and Explosibility

Flammable

Synthesis

Method one is to synthesize piperazine as raw material: piperazine is prepared by reacting with acetonitrile, acetaldehyde or ethyl bromide. The method of synthesizing N-ethyl piperazine by reaction of piperazine and ethyl bromide has the features of simple production process and less by-products, which is a new process with more research in China, but the reaction has the fatal shortcomings of high production cost and low profit margin, which seriously restricts the industrialization of this process, and at the same time, in the process of reaction of piperazine and ethyl bromide, there are inevitably more by-products of N,N-Diethylpiperazine generation. The second method is to synthesize with ethylamine as raw material: ethylamine and ethylene oxide are prepared by addition and cyclization. The disadvantages of this method are high reaction temperature, resulting in high equipment requirements; more reaction steps, more equipment instrumentation, resulting in process control, three waste disposal difficulties; poor catalyst selectivity, low conversion rate, more by-products.

1-Ethylpiperazine Preparation Products And Raw materials

Raw materials

Ethanol CHLOROETHANE Piperazine Sodium iodide Hydrochloric acid Sodium hydroxide

Preparation Products

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1-Ethylpiperazine Suppliers

Americas 1 Belgium 2 Canada 1 China 388 Europe 4 France 1 Germany 12 India 49 Japan 8 Singapore 1 Slovakia 1 South Korea 2 Switzerland 6 The Netherlands 2 Ukraine 1 United Kingdom 14 United States 48 Global 541

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.

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Energy Chemical

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View Lastest Price from 1-Ethylpiperazine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Ethylpiperazine 5308-25-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

Moxin Chemicals

Product: Abemaciclib Impurity 38 5308-25-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000
Release date: 2025-03-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1-Ethylpiperazine 5308-25-8
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-31

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NEPRZ

AKOS BBS-00003610

TIMTEC-BB SBB006719

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