1-(4-Chlorobenzhydryl)piperazine

Product Name: 1-(4-Chlorobenzhydryl)piperazine
CAS No.: 303-26-4
Chemical Name: 1-(4-Chlorobenzhydryl)piperazine
Synonyms: Norchlorcyclizine;Hydroxyzine Related CoMpound A;1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE;NSC 8616;USP CBHP;NSC 86164;UNII:T875VN0D6E;AKOS BBS-00003606;Cetirizine USP A;TIMTEC-BB SBB002998
CBNumber: CB6297354
Molecular Formula: C17H19ClN2
Formula Weight: 286.8
MOL File: 303-26-4.mol

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1-(4-Chlorobenzhydryl)piperazine Property

Melting point:: 65-70 °C (lit.)
Boiling point:: 178-180 °C/0.5 mmHg (lit.)
Density: 1.0912 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.5749 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: soluble in Methanol
form: Crystalline Powder
pka: 8.99±0.10(Predicted)
color: White to light beige
Water Solubility: 144.6mg/L at 25℃
LogP: 3.4 at 25℃
CAS DataBase Reference: 303-26-4(CAS DataBase Reference)
NIST Chemistry Reference: Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
RTECS: TL1772000
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2872
Product name: Hydroxyzine Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $461
Updated: 2024/03/01

Sigma-Aldrich

Product number: C24507
Product name: 1-(4-Chlorobenzhydryl)piperazine
Purity: technical grade, 90%
Packaging: 1g
Price: $53.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1333058
Product name: Hydroxyzine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1490
Updated: 2024/03/01

TCI Chemical

Product number: C1611
Product name: 1-(4-Chlorobenzhydryl)piperazine
Purity: >98.0%(GC)
Packaging: 1g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: C1611
Product name: 1-(4-Chlorobenzhydryl)piperazine
Purity: >98.0%(GC)
Packaging: 5g
Price: $136
Updated: 2024/03/01

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1-(4-Chlorobenzhydryl)piperazine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.

Uses

Cetrizine Dihydrochloride intermediate

Preparation

Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.

Flammability and Explosibility

Not classified

Safety Profile

An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.

1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium iodide Calcium chloride Toluene Potassium carbonate 2-Butanone Piperazine 4-Chlorobenzhydrol Ethyl acetate Dichloromethane Methanol Magnesium sulfate Thionyl chloride PETROLEUM ETHER

Preparation Products

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1-(4-Chlorobenzhydryl)piperazine Suppliers

Americas 1 Belgium 1 Canada 2 China 214 Europe 4 Germany 5 India 46 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 12 United States 47 Global 341

Shanghai Qiao Chemical Science Co., Ltd

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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View Lastest Price from 1-(4-Chlorobenzhydryl)piperazine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2022-12-13

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000ton
Release date: 2024-05-07

303-26-4, 1-(4-Chlorobenzhydryl)piperazineRelated Search:

2-Diphenylmethylpiperidine hydrochloride 1-Methylpiperazine 2-Methylpiperazine 4-(Chloromethyl)benzoic acid Vinylbenzyl chloride 1-BENZHYDRYLPIPERAZINE tert-Butyldimethylsilyl chloride 1,2-Dimethylhydrazine Dihydrochloride DIMETHYLTHEXYLSILYL CHLORIDE Piperazine N,N'-Dimethylpiperazine 2,6-Dimethylpiperazine Hydroxyzine dihydrochloride Hydroxydiethylphenamine Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Cetirizine EP Impurity E Cetirizine EP Impurity B (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride

1-((4-chlorophenyl)phenylmethyl)-piperazin

1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE

(1-(p-Chloro- -phenylbenzyl)-piperazine

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-

NSC 86164

1-(4-Chloro-a-phenylbenzyl)piperazine

4-(α-Piperazinobenzyl)phenyl chloride

1-(4-Chlorobenzhydry)piperazine

Piperazine, 1-(alpha-(4-chloropheny

Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine)

1-(4-Chlorobenzhydryl)piperazine, 90-95% 5GR

1-(4-chlorobenzhydryl)

Buclizine HCl IMpurity (BP/EP)

Cetirizine IMpurity-A(EP/BP)

Levocetrizine EP IMpurity A

1-(1-4-Chlorobenzhdryl) piperazine

Hydroxyzine Related CoMpound A

Meclozine impurity H

Cetirizine EP Impurity A

Hydroxyzine EP Impurity A

Cetirizine -EP-Imp-A

Cetirizine Impurity 9（Cetirizine EP Impurity A）

Buclizine Impurity 1

1-(4-Chloro-alpha-phenylbenzyl)piperazine

1-(alpha-Phenyl-4-chlorobenzyl)piperazine

1-(p-chloro-alpha-phenylbenzyl)-piperazin

4-(4-Chlorobenzhydryl)piperazine

Norchlorcyclizine

Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-

Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-

N-(4-Chlorophenyl)phenylmethylpiperazine

1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH.,

4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp

AKOS BBS-00003606

1-(4-CHLOROBENZHYDRYL)PIPERAZINE

1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE

1-(4-CHLOROPHENYLMETHYL)PIPERAZINE

1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE

N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE

N-(4-CHLOROBENZHYDRYL)-PIPERAZINE

N-(P-CHLOROBENZHYDRYL)-PIPERAZINE

TIMTEC-BB SBB002998

1-(4-Chlorobenzhydryl)piperazine, 90-95%

1-(p-Chloro-a-phenylbenzyl)-piperazine

NSC 8616

1-(p-chloro-alpha-phenylbenzyl)-piperazine

1-(4-Chlorobenzhydryl)piperazine technical grade, 90%

1-(4-Chlorobenzhydryl)-piperizine

Cetirizine Impurity 13

Cetirizine Dihydrochloride impurity A

4-CHLORO BENZHYDRYL PIPERAZINE ( PARA CHLORO BENZHYDRYL PIPERAZINE ) ( INTERMEDIATE FOR CETIRIZINE HCL E. P. / B. P. )

Hydroxyzine Impurity 1(Hydroxyzine EP Impurity A)

(RS)-1-[(4-Chlorophenyl)phenylmethy

1-(4-Chlorobenzhydryl)piperazine &gt

Cetirizine impurity A CRS

Meclozine impurity H CRS

Meclizine EP Impurity H

USP CBHP