ChemicalBook > CAS DataBase List > 1-(4-Chlorobenzhydryl)piperazine

1-(4-Chlorobenzhydryl)piperazine

Product Name
1-(4-Chlorobenzhydryl)piperazine
CAS No.
303-26-4
Chemical Name
1-(4-Chlorobenzhydryl)piperazine
Synonyms
Norchlorcyclizine;Hydroxyzine Related CoMpound A;1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE;NSC 8616;USP CBHP;NSC 86164;AKOS BBS-00003606;Cetirizine USP A;TIMTEC-BB SBB002998;Cetirizine -EP-Imp-A
CBNumber
CB6297354
Molecular Formula
C17H19ClN2
Formula Weight
286.8
MOL File
303-26-4.mol
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1-(4-Chlorobenzhydryl)piperazine Property

Melting point:
65-70 °C (lit.)
Boiling point:
178-180 °C/0.5 mmHg (lit.)
Density 
1.0912 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5749 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
Crystalline Powder
pka
8.99±0.10(Predicted)
color 
White to light beige
Water Solubility 
144.6mg/L at 25℃
LogP
3.4 at 25℃
CAS DataBase Reference
303-26-4(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
RTECS 
TL1772000
Hazard Note 
Irritant
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2872
Product name
Hydroxyzine Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
C24507
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
technical grade, 90%
Packaging
1g
Price
$53.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1333058
Product name
Hydroxyzine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1490
Updated
2024/03/01
TCI Chemical
Product number
C1611
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
>98.0%(GC)
Packaging
1g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
C1611
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
>98.0%(GC)
Packaging
5g
Price
$136
Updated
2024/03/01
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1-(4-Chlorobenzhydryl)piperazine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.

Uses

Cetrizine Dihydrochloride intermediate

Preparation

Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.

Flammability and Explosibility

Not classified

Safety Profile

An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.

1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium iodide Calcium chloride Toluene Potassium carbonate 2-Butanone Piperazine 4-Chlorobenzhydrol Ethyl acetate Dichloromethane Methanol Magnesium sulfate Thionyl chloride PETROLEUM ETHER

Preparation Products

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View Lastest Price from 1-(4-Chlorobenzhydryl)piperazine manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2022-12-13
Hebei Yanxi Chemical Co., Ltd.
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Henan Aochuang Chemical Co.,Ltd.
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

303-26-4, 1-(4-Chlorobenzhydryl)piperazineRelated Search:

2-Diphenylmethylpiperidine hydrochloride 1-Methylpiperazine 2-Methylpiperazine 4-(Chloromethyl)benzoic acid Vinylbenzyl chloride 1-BENZHYDRYLPIPERAZINE tert-Butyldimethylsilyl chloride 1,2-Dimethylhydrazine Dihydrochloride DIMETHYLTHEXYLSILYL CHLORIDE Piperazine N,N'-Dimethylpiperazine 2,6-Dimethylpiperazine Hydroxyzine dihydrochloride Hydroxydiethylphenamine Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Cetirizine EP Impurity E Cetirizine EP Impurity B (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride

  • 1-((4-chlorophenyl)phenylmethyl)-piperazin
  • 1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE
  • (1-(p-Chloro- -phenylbenzyl)-piperazine
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-
  • NSC 86164
  • 1-(4-Chloro-a-phenylbenzyl)piperazine
  • 4-(α-Piperazinobenzyl)phenyl chloride
  • 1-(4-Chlorobenzhydry)piperazine
  • Piperazine, 1-(alpha-(4-chloropheny
  • Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine)
  • 1-(4-Chlorobenzhydryl)piperazine, 90-95% 5GR
  • 1-(4-chlorobenzhydryl)
  • Buclizine HCl IMpurity (BP/EP)
  • Cetirizine IMpurity-A(EP/BP)
  • Levocetrizine EP IMpurity A
  • 1-(1-4-Chlorobenzhdryl) piperazine
  • Hydroxyzine Related CoMpound A
  • Meclozine impurity H
  • Cetirizine EP Impurity A
  • Hydroxyzine EP Impurity A
  • Cetirizine -EP-Imp-A
  • Cetirizine Impurity 9（Cetirizine EP Impurity A）
  • Buclizine Impurity 1
  • 1-(4-Chloro-alpha-phenylbenzyl)piperazine
  • 1-(alpha-Phenyl-4-chlorobenzyl)piperazine
  • 1-(p-chloro-alpha-phenylbenzyl)-piperazin
  • 4-(4-Chlorobenzhydryl)piperazine
  • Norchlorcyclizine
  • Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-
  • N-(4-Chlorophenyl)phenylmethylpiperazine
  • 1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH.,
  • 4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp
  • AKOS BBS-00003606
  • 1-(4-CHLOROBENZHYDRYL)PIPERAZINE
  • 1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE
  • 1-(4-CHLOROPHENYLMETHYL)PIPERAZINE
  • 1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE
  • N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE
  • N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
  • N-(P-CHLOROBENZHYDRYL)-PIPERAZINE
  • TIMTEC-BB SBB002998
  • 1-(4-Chlorobenzhydryl)piperazine, 90-95%
  • 1-(p-Chloro-a-phenylbenzyl)-piperazine
  • NSC 8616
  • 1-(p-chloro-alpha-phenylbenzyl)-piperazine
  • 1-(4-Chlorobenzhydryl)piperazine technical grade, 90%
  • 1-(4-Chlorobenzhydryl)-piperizine
  • Cetirizine Impurity 13
  • Cetirizine Dihydrochloride impurity A
  • 4-CHLORO BENZHYDRYL PIPERAZINE ( PARA CHLORO BENZHYDRYL PIPERAZINE ) ( INTERMEDIATE FOR CETIRIZINE HCL E. P. / B. P. )
  • Hydroxyzine Impurity 1(Hydroxyzine EP Impurity A)
  • (RS)-1-[(4-Chlorophenyl)phenylmethy
  • 1-(4-Chlorobenzhydryl)piperazine &gt
  • Cetirizine impurity A CRS
  • Meclozine impurity H CRS
  • Meclizine EP Impurity H
  • USP CBHP