ChemicalBook > CAS DataBase List > 1-(4-Chlorobenzhydryl)piperazine

1-(4-Chlorobenzhydryl)piperazine

Product Name
1-(4-Chlorobenzhydryl)piperazine
CAS No.
303-26-4
Chemical Name
1-(4-Chlorobenzhydryl)piperazine
Synonyms
Norchlorcyclizine;Hydroxyzine Related CoMpound A;1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE;NSC 8616;USP CBHP;NSC 86164;UNII:T875VN0D6E;AKOS BBS-00003606;Cetirizine USP A;TIMTEC-BB SBB002998
CBNumber
CB6297354
Molecular Formula
C17H19ClN2
Formula Weight
286.8
MOL File
303-26-4.mol
More
Less

1-(4-Chlorobenzhydryl)piperazine Property

Melting point:
65-70 °C (lit.)
Boiling point:
178-180 °C/0.5 mmHg (lit.)
Density 
1.0912 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5749 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
Crystalline Powder
pka
8.99±0.10(Predicted)
color 
White to light beige
Water Solubility 
144.6mg/L at 25℃
LogP
3.4 at 25℃
CAS DataBase Reference
303-26-4(CAS DataBase Reference)
NIST Chemistry Reference
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
RTECS 
TL1772000
Hazard Note 
Irritant
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2872
Product name
Hydroxyzine Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
C24507
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
technical grade, 90%
Packaging
1g
Price
$53.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1333058
Product name
Hydroxyzine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1490
Updated
2024/03/01
TCI Chemical
Product number
C1611
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
>98.0%(GC)
Packaging
1g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
C1611
Product name
1-(4-Chlorobenzhydryl)piperazine
Purity
>98.0%(GC)
Packaging
5g
Price
$136
Updated
2024/03/01
More
Less

1-(4-Chlorobenzhydryl)piperazine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.

Uses

Cetrizine Dihydrochloride intermediate

Preparation

Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.

Flammability and Explosibility

Not classified

Safety Profile

An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.

1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium iodide Calcium chloride Toluene Potassium carbonate 2-Butanone Piperazine 4-Chlorobenzhydrol Ethyl acetate Dichloromethane Methanol Magnesium sulfate Thionyl chloride PETROLEUM ETHER

Preparation Products

More
Less

1-(4-Chlorobenzhydryl)piperazine Suppliers

Americas 1 Belgium 1 Canada 2 China 214 Europe 4 Germany 5 India 46 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 12 United States 47 Global 341
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5902
Advantage
65
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18912868361
Fax
QQ1907456386
Email
sales2@btcpharm.com
Country
China
ProdList
1329
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1230
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Zhemical Co., Ltd.
Tel
0760-89935616
Fax
+86 (760) 8533-0775
Email
zc@zhemical.com
Country
China
ProdList
172
Advantage
57
RYSS TECH LTD
Tel
400-188-0725 +86 21 34310725 13611771617
Fax
+86 21 34311076
Country
China
ProdList
2002
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2872
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4954
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1874
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Conier Chem & Pharma Co.,Ltd,
Tel
023-62879767 13996269627;
Fax
+86-28-84559521
Email
sales@conier.com
Country
China
ProdList
294
Advantage
56
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
ChemiK Co., Ltd.
Tel
+86 574 8729 6330
Fax
+86 574 8729 7461
Email
info@chemik.com
Country
China
ProdList
3616
Advantage
61
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10021
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Qufu Haida Tiancheng Biochemical Co., Ltd.
Tel
0537-4531868 18553729317
Email
hdchem@126.com
Country
China
ProdList
88
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
3429815786 13301662590
Fax
+86-21-51619052
Email
Mandy@ATKchemical.com
Country
China
ProdList
8026
Advantage
55
More
Less

View Lastest Price from 1-(4-Chlorobenzhydryl)piperazine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2022-12-13
Shaanxi Dideu Medichem Co. Ltd
Product
1-(4-Chlorobenzhydryl)piperazine 303-26-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000ton
Release date
2024-05-07

303-26-4, 1-(4-Chlorobenzhydryl)piperazineRelated Search:

2-Diphenylmethylpiperidine hydrochloride 1-Methylpiperazine 2-Methylpiperazine 4-(Chloromethyl)benzoic acid Vinylbenzyl chloride 1-BENZHYDRYLPIPERAZINE tert-Butyldimethylsilyl chloride 1,2-Dimethylhydrazine Dihydrochloride DIMETHYLTHEXYLSILYL CHLORIDE Piperazine N,N'-Dimethylpiperazine 2,6-Dimethylpiperazine Hydroxyzine dihydrochloride Hydroxydiethylphenamine Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Cetirizine EP Impurity E Cetirizine EP Impurity B (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride

  • 1-((4-chlorophenyl)phenylmethyl)-piperazin
  • 1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE
  • (1-(p-Chloro- -phenylbenzyl)-piperazine
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-
  • NSC 86164
  • 1-(4-Chloro-a-phenylbenzyl)piperazine
  • 4-(α-Piperazinobenzyl)phenyl chloride
  • 1-(4-Chlorobenzhydry)piperazine
  • Piperazine, 1-(alpha-(4-chloropheny
  • Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine)
  • 1-(4-Chlorobenzhydryl)piperazine, 90-95% 5GR
  • 1-(4-chlorobenzhydryl)
  • Buclizine HCl IMpurity (BP/EP)
  • Cetirizine IMpurity-A(EP/BP)
  • Levocetrizine EP IMpurity A
  • 1-(1-4-Chlorobenzhdryl) piperazine
  • Hydroxyzine Related CoMpound A
  • Meclozine impurity H
  • Cetirizine EP Impurity A
  • Hydroxyzine EP Impurity A
  • Cetirizine -EP-Imp-A
  • Cetirizine Impurity 9（Cetirizine EP Impurity A）
  • Buclizine Impurity 1
  • 1-(4-Chloro-alpha-phenylbenzyl)piperazine
  • 1-(alpha-Phenyl-4-chlorobenzyl)piperazine
  • 1-(p-chloro-alpha-phenylbenzyl)-piperazin
  • 4-(4-Chlorobenzhydryl)piperazine
  • Norchlorcyclizine
  • Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-
  • N-(4-Chlorophenyl)phenylmethylpiperazine
  • 1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH.,
  • 4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp
  • AKOS BBS-00003606
  • 1-(4-CHLOROBENZHYDRYL)PIPERAZINE
  • 1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE
  • 1-(4-CHLOROPHENYLMETHYL)PIPERAZINE
  • 1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE
  • N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE
  • N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
  • N-(P-CHLOROBENZHYDRYL)-PIPERAZINE
  • TIMTEC-BB SBB002998
  • 1-(4-Chlorobenzhydryl)piperazine, 90-95%
  • 1-(p-Chloro-a-phenylbenzyl)-piperazine
  • NSC 8616
  • 1-(p-chloro-alpha-phenylbenzyl)-piperazine
  • 1-(4-Chlorobenzhydryl)piperazine technical grade, 90%
  • 1-(4-Chlorobenzhydryl)-piperizine
  • Cetirizine Impurity 13
  • Cetirizine Dihydrochloride impurity A
  • 4-CHLORO BENZHYDRYL PIPERAZINE ( PARA CHLORO BENZHYDRYL PIPERAZINE ) ( INTERMEDIATE FOR CETIRIZINE HCL E. P. / B. P. )
  • Hydroxyzine Impurity 1(Hydroxyzine EP Impurity A)
  • (RS)-1-[(4-Chlorophenyl)phenylmethy
  • 1-(4-Chlorobenzhydryl)piperazine &gt
  • Cetirizine impurity A CRS
  • Meclozine impurity H CRS
  • Meclizine EP Impurity H
  • USP CBHP