HEPPS
- Product Name
- HEPPS
- CAS No.
- 16052-06-5
- Chemical Name
- HEPPS
- Synonyms
- HEPE;EPPS;aEPPS;HEPPS;EPPS,99%;HEPPS(EPPS);HEPPS Buffer;EPPS USP/EP/BP;EPPS SIGMAULTRA;HEPPS ULTRAPURE
- CBNumber
- CB9310937
- Molecular Formula
- C9H20N2O4S
- Formula Weight
- 252.33
- MOL File
- 16052-06-5.mol
HEPPS Property
- Melting point:
- 237-239 °C(lit.)
- Density
- 1.2684 (rough estimate)
- refractive index
- 1.6800 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: 1 M at 20 °C, clear, colorless
- form
- Powder/Solid
- color
- White
- PH Range
- 7.3 - 8.7
- PH
- 5.0-6.5 (25℃, 0.1M in H2O)
- pka
- 8.0(at 25℃)
- Water Solubility
- Soluble in water. 25.2 g/L (20°C)
- λmax
- λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045 - BRN
- 3957385
- CAS DataBase Reference
- 16052-06-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- RTECS
- TM2649130
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29335995
- Toxicity
- quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- E0276
- Product name
- EPPS
- Purity
- BioPerformance Certified, cell culture tested, ≥99.5% (titration)
- Packaging
- 25g
- Price
- $57.5
- Updated
- 2023/06/20
- Product number
- H0576
- Product name
- 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component for biological research]
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- A13714
- Product name
- EPPS, 99%
- Packaging
- 25g
- Price
- $31.65
- Updated
- 2024/03/01
- Product number
- A13714
- Product name
- EPPS, 99%
- Packaging
- 100g
- Price
- $100
- Updated
- 2024/03/01
- Product number
- E9502
- Product name
- EPPS
- Purity
- ≥99.5% (titration)
- Packaging
- 10g
- Price
- $28.08
- Updated
- 2024/03/01
HEPPS Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.
Definition
ChEBI: HEPPS is a N-(sulfoalkyl)piperazine and a N-(2-hydroxyethyl)piperazine.
General Description
HEPPS, or N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), is a zwitterionic buffering agent commonly used in biochemical and molecular biology research. Its mechanism of action is rooted in its ability to maintain a stable pH environment, which is crucial for various enzymatic reactions and protein studies. HEPPS is especially favoured for its buffering capacity in the physiological pH range, typically between pH 6.8 and 8.2, making it ideal for biological assays and cell culture experiments. This compound is extensively utilized in preparing cell culture media, where maintaining a consistent pH is essential for cell viability and growth. Additionally, HEPPS is employed in biochemical assays, such as enzyme kinetics studies, where precise pH control is necessary to accurately measure enzymatic activity. Furthermore, HEPPS has found applications in molecular biology techniques, including nucleic acid purification, PCR (polymerase chain reaction), and protein analysis by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). Its compatibility with various biological systems and stability under physiological conditions make HEPPS a valuable tool in research laboratories for maintaining optimal pH conditions and ensuring reliable experimental outcomes in various biochemical and molecular biology studies.
Flammability and Explosibility
Not classified
HEPPS Preparation Products And Raw materials
Raw materials
Preparation Products
HEPPS Suppliers
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View Lastest Price from HEPPS manufacturers
- Product
- HEPPS 16052-06-5
- Price
- US $32.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-15
- Product
- HEPPS 16052-06-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 3500kg/month
- Release date
- 2021-09-09
- Product
- EPPS 16052-06-5
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000
- Release date
- 2024-03-28