ChemicalBook > CAS DataBase List > HEPPS

HEPPS

Product Name
HEPPS
CAS No.
16052-06-5
Chemical Name
HEPPS
Synonyms
HEPE;EPPS;aEPPS;HEPPS;EPPS,99%;HEPPS(EPPS);HEPPS Buffer;EPPS USP/EP/BP;EPPS SIGMAULTRA;HEPPS ULTRAPURE
CBNumber
CB9310937
Molecular Formula
C9H20N2O4S
Formula Weight
252.33
MOL File
16052-06-5.mol
More
Less

HEPPS Property

Melting point:
237-239 °C(lit.)
Density 
1.2684 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Powder/Solid
color 
White
PH Range
7.3 - 8.7
PH
5.0-6.5 (25℃, 0.1M in H2O)
pka
8.0(at 25℃)
Water Solubility 
Soluble in water. 25.2 g/L (20°C)
λmax
λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
BRN 
3957385
CAS DataBase Reference
16052-06-5(CAS DataBase Reference)
EPA Substance Registry System
1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-22
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
TM2649130
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29335995
Toxicity
quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E0276
Product name
EPPS
Purity
BioPerformance Certified, cell culture tested, ≥99.5% (titration)
Packaging
25g
Price
$57.5
Updated
2023/06/20
TCI Chemical
Product number
H0576
Product name
4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component for biological research]
Purity
>98.0%(T)
Packaging
25g
Price
$108
Updated
2024/03/01
Alfa Aesar
Product number
A13714
Product name
EPPS, 99%
Packaging
25g
Price
$31.65
Updated
2024/03/01
Alfa Aesar
Product number
A13714
Product name
EPPS, 99%
Packaging
100g
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
E9502
Product name
EPPS
Purity
≥99.5% (titration)
Packaging
10g
Price
$28.08
Updated
2024/03/01
More
Less

HEPPS Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.

Definition

ChEBI: HEPPS is a N-(sulfoalkyl)piperazine and a N-(2-hydroxyethyl)piperazine.

General Description

HEPPS, or N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), is a zwitterionic buffering agent commonly used in biochemical and molecular biology research. Its mechanism of action is rooted in its ability to maintain a stable pH environment, which is crucial for various enzymatic reactions and protein studies. HEPPS is especially favoured for its buffering capacity in the physiological pH range, typically between pH 6.8 and 8.2, making it ideal for biological assays and cell culture experiments. This compound is extensively utilized in preparing cell culture media, where maintaining a consistent pH is essential for cell viability and growth. Additionally, HEPPS is employed in biochemical assays, such as enzyme kinetics studies, where precise pH control is necessary to accurately measure enzymatic activity. Furthermore, HEPPS has found applications in molecular biology techniques, including nucleic acid purification, PCR (polymerase chain reaction), and protein analysis by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). Its compatibility with various biological systems and stability under physiological conditions make HEPPS a valuable tool in research laboratories for maintaining optimal pH conditions and ensuring reliable experimental outcomes in various biochemical and molecular biology studies.

Flammability and Explosibility

Not classified

HEPPS Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

HEPPS Suppliers

Americas 1 Belgium 2 China 256 Czech Republic 1 Europe 5 France 1 Germany 11 India 13 Japan 5 Poland 1 Russia 1 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 19 United States 36 Global 356
Opteby Scientific GmbH
Tel
--
Fax
--
Email
anfragen@opteby.com
Country
Germany
ProdList
170
Advantage
58
Dojindo EU GmbH
Tel
--
Fax
--
Email
info@dojindo.eu.com
Country
Germany
ProdList
62
Advantage
58
Sinus Biochemistry & Electrophoresis GmbH
Tel
--
Fax
--
Email
m.demharter@sinus-biochem.de
Country
Germany
ProdList
621
Advantage
68
SERVA Electrophoresis GmbH
Tel
--
Fax
--
Email
info@serva.de
Country
Germany
ProdList
1142
Advantage
80
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
968
Advantage
65
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Raschig GmbH
Tel
--
Fax
--
Email
vch@raschig.de
Country
Germany
ProdList
184
Advantage
64
Merck Schuchardt OHG
Tel
--
Fax
--
Email
schuchardt-vertrieb@merck.de
Country
Germany
ProdList
5827
Advantage
74
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
1607
Advantage
74
Labotest
Tel
--
Fax
--
Email
sales@labotest.com
Country
Germany
ProdList
3564
Advantage
42
More
Less

View Lastest Price from HEPPS manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
HEPPS 16052-06-5
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-15
WUHAN FORTUNA CHEMICAL CO., LTD
Product
HEPPS 16052-06-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
3500kg/month
Release date
2021-09-09
hebei hongtan Biotechnology Co., Ltd
Product
EPPS 16052-06-5
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-28

16052-06-5, HEPPSRelated Search:

1-Ethylpiperazine Folic acid Calcium dobesilate 2-(METHYLSULFONYL)ETHANOL Citric acid 2-Hydroxyethanesulphonic acid Sodium ethylenesulphonate 2-Ethylpiperazine Hydroxyethyl Cellulose Piperazine HEPES Sodium isethionate Hydroxyethyl starch 2-Piperidinoethanol N-Aminoethylpiperazine 1-(2-Hydroxyethyl)piperazine Ascoric Acid HEPPSO

  • HEPPS(EPPS)
  • 4-(2-Hydroxyethyl)pi
  • HEPE
  • 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]PROPANESULFONIC ACID
  • 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]PROPANESULFONIC ACID
  • N-(2-HYDROXYETHYL)-N'-(3-SULFOPROPYL)-PIPERAZINE
  • N-[2-HYDROXYETHYL]PIPERAZINE-N'-[3-PROPANESULFONIC ACID]
  • N-2-HYDROXYETHYLPIPERAZINE-N'-3-PROPANESULPHONIC ACID
  • aEPPS
  • HEPPS N-(2-Hydroxyethyl)piperazine-N-3-propanesulfonic acid
  • HEPPS, ULTROL Grade
  • HEPPS~4-(2-Hydroxyethyl)-1-piperazinepropanesulphonic acid
  • EPPS FREE ACID, BIOTECHNOLOGY PERFORMANC E CERTIFIED
  • EPPS, 99% (4-(2-HYDROXYETHYL)-1-PIPERAZI NE -PROPANESULFONIC ACID)
  • EPPS SIGMAULTRA
  • HEPPS CELL CULTURE REAGENT CRYSTALLINE
  • EPPS 99% (4-(2-HYDROXYETHYL)-1-PIPERAZINE -PROPANESULFONIC ACID) 99+% ULTRA PURE BUFFER GRADE
  • EPPS, for biochemistry, 99%
  • Hydroxyethyl)piperazine-N'-3-propane-sulfonic acid
  • 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
  • 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid
  • N-(hydroxyethyl)piperazine-N’-propanesulfonic acid (HEPPS)
  • 4-(2-HYDROXYETHYL)-1-PIPERAZINEPROPANESULFONIC ACID EPPS
  • HEPPS ULTRAPURE
  • HEPPS (4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID)
  • 3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic
  • N-(2-Hydroxyethyl)piperazine-N'-(propanesulphonic acid)
  • HEPPS, ≥99.0%(T)
  • HEPPS, ≥99.5%(T)
  • 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID;EPPS
  • 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid&nbsp
  • HEPPS/EPPS/HEPE
  • 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid[HEPPS]
  • HEPPS 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid
  • 4-Hydroxyerhylpiperazine-1-propanesulfonic acid
  • EPPS,99%
  • EPPS Vetec(TM) reagent grade, 99%
  • HEPPS/ 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid
  • 4-(2-hydroxyethyl)-1-piperazinepropanesulfonicaci
  • EPPS
  • HEPPS
  • LABOTEST-BB LT00138110
  • 4-(2-HYDROXYETHYL)-1-PIPERAZINEPROPANESULFONIC ACID
  • 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID
  • N-(2-Hydroxyethyl)piperazine-N'-3-propanesulphonic acid >99%
  • 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component for biological research]
  • Epps, 99%, for biochemistry
  • HeppsN-(2-Hydroxyethyl)Piperazine-NPropanesulfonicAcid
  • Epps(N-[2-Hydroxyethyl]Piperazine-N3-PropaneSulfonicAcid])
  • 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid
  • 3-[4-(2-Hydroxyethyl)piperazine-1-yl]-1-propanesulfonic acid
  • 3-[4-(2-Hydroxyethyl)piperazino]-1-propanesulfonic acid
  • 4-(2-Hydroxyethyl)-1-piperazinepropane-1-sulfonic acid
  • HEPPS Buffer
  • 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, HEPPS, N-(2-Hydroxyethyl)piperazine-Nμ-(3-propanesulfonic acid)
  • 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
  • [2-hydroxyethyl]piperazine-n’-[3-propancesulfonicacid]
  • N-(Hydroxyethyl)piperazine-N'-propane sulfonic acid