ChemicalBook > CAS DataBase List > 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

Product Name: 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-
CAS No.: 706811-25-8
Chemical Name: 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-
Synonyms: Macitentan Impurity 25;Macitentan Impurity 25 CRS;5-(4-broMophenyl)pyriMidine-4,6-diol;5-(4-Bromophenyl)-4,6-pyrimidinediol;5-(4-Bromophenyl)-4,6-dihydroxpyrimidine;5-(4-broMophenyl)pyriMidine-4,6(1H,5H)-dione;5-(4-bromophenyl)-6-hydroxypyrimidin-4(3H)-one;5-(4-bromophenyl)-4-hydroxy-1H-pyrimidin-6-one;5-(4-Bromophenyl)-6-hydroxypyrimidin-4(1H)-one;5-(4-broMophenyl)-6-hydroxy- 4(1H)-PyriMidinone
CBNumber: CB72623954
Molecular Formula: C10H7BrN2O2
Formula Weight: 267.08
MOL File: 706811-25-8.mol

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4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Property

Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.69±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C10H7BrN2O2/c11-7-3-1-6(2-4-7)8-9(14)12-5-13-10(8)15/h1-5H,(H2,12,13,14,15)
InChIKey: PIUMVXYVNAISNG-UHFFFAOYSA-N
SMILES: C1NC(O)=C(C2=CC=C(Br)C=C2)C(=O)N=1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0056AP
Product name: 4(1H)-Pyrimidinone,5-(4-bromophenyl)-6-hydroxy
Packaging: 1g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR55029
Product name: 5-(4-Bromophenyl)pyrimidine-4,6-diol
Packaging: 1g
Price: $182
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-9D
Product name: 5-(4-Bromophenyl)pyrimidine-4,6-diol
Packaging: 1g
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR55029
Product name: 5-(4-Bromophenyl)pyrimidine-4,6-diol
Packaging: 5g
Price: $508
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-9D
Product name: 5-(4-Bromophenyl)pyrimidine-4,6-diol
Packaging: 5G
Price: $560
Updated: 2021/12/16

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4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Chemical Properties,Usage,Production

Uses

5-(4-Bromophenyl)pyrimidine-4,6-diol is used in preparation of pharmaceutical intermediate of Macitentan.

Synthesis

77287-34-4

149506-35-4

706811-25-8

To a stirred solution of 100 g of dimethyl 2-(4-bromophenyl)malonate (0.348 mol) dissolved in 400 cm3 methanol at 20-25 °C, 30 g of formamide (0.66 mol) and 30 g of sodium methanolate (0.555 mol) were added sequentially. The reaction mixture was heated to 70 °C and maintained at this temperature until the reaction was complete (monitored by HPLC). After completion of the reaction, methanol was removed by distillation under reduced pressure at 70°C to give a syrupy substance. The syrup was cooled to 25-30 °C and diluted with 2 dm3 water. The pH of the solution was adjusted to 2-2.5 with concentrated hydrochloric acid and this pH was maintained for 45 min. The precipitated solid was collected by filtration and washed with water until the filtrate reached pH 7-7.5. The product was blotted dry and dried under reduced pressure at 100°C to give the crude product 5-(4-bromophenyl)-6-hydroxypyrimidin-4(1H)-one. The crude product was dissolved in 500 cm3 methanol and heated to 60-65°C and kept for 1 hour. The reaction mixture was then cooled to 25-30°C and left to stand for 30 minutes. The resulting solid was filtered, washed with methanol and dried under reduced pressure at 50-55°C to give the pure product 5-(4-bromophenyl)-6-hydroxypyrimidin-4(1H)-one. Yield: 70 g (75.25%); HPLC purity: 99.5%; melting point: 176-180 °C. The spectral data of the obtained compounds were in agreement with literature reports [8].

References

[1] Monatshefte fur Chemie, 2018, vol. 149, # 3, p. 653 - 661

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone 706811-25-8
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-24

Career Henan Chemical Co

Product: 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- 706811-25-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 500kg
Release date: 2019-07-05

706811-25-8, 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-Related Search:

Macitidine related impurities PropylsulfaMide CarbaMic acid, N-[(propylaMino)sulfonyl]-, phenylMethyl ester N-Propylsulfuric diamide-sodium SulfaMide, N-propyl-,(potassiuM salt)(1:1) Macitentan impurity A 5-Bromo-2-chloropyrimidine 5-(4-Bromophenyl)-4,6-dichloropyrimidine 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER Macitentan impurity B macitentan ACT 080803 Macitentan IMpurity Masitatin impurity 1 NA Macitidine impurity 2 Masitatin impurity 3 Macitidine impurity 5

4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

5-(4-broMophenyl)pyriMidine-4,6(1H,5H)-dione

5-(4-broMophenyl)-6-hydroxy- 4(1H)-PyriMidinone

5-(4-broMophenyl)pyriMidine-4,6-diol

5-(4-Bromophenyl)-6-hydroxypyrimidin-4(1H)-one

Macitentan Impurity 25

5-(4-Bromophenyl)-4,6-pyrimidinediol

5-(4-bromophenyl)-4-hydroxy-1H-pyrimidin-6-one

5-(4-bromophenyl)-6-hydroxypyrimidin-4(3H)-one

Macitentan Impurity 25 CRS

5-(4-Bromophenyl)-4,6-dihydroxpyrimidine

(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-

706811-25-8