ChemicalBook > CAS DataBase List > AIM-100

AIM-100

Product Name
AIM-100
CAS No.
873305-35-2
Chemical Name
AIM-100
Synonyms
AIM-100;AIM 100;AIM100;AIM-100, 10 mM in DMSO;(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine;(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine;Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-;TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer
CBNumber
CB72624072
Molecular Formula
C23H21N3O2
Formula Weight
371.43
MOL File
873305-35-2.mol
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AIM-100 Property

Boiling point:
552.9±50.0 °C(Predicted)
Density 
1.243±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
form 
Powder
pka
4.62±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29487
Product name
AIM 100
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29487
Product name
AIM 100
Packaging
50mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
29487
Product name
AIM 100
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
29487
Product name
AIM 100
Packaging
25mg
Price
$343
Updated
2024/03/01
Tocris
Product number
4946
Product name
AIM100
Purity
≥98%(HPLC)
Packaging
10
Price
$214
Updated
2021/12/16
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AIM-100 Chemical Properties,Usage,Production

Uses

AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth.

Biological Activity

aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2].

in vivo

In male nude castrated mice, AIM-100 (4 mg/kg) suppresses growth of radioresistant castration-resistant prostate cancer (CRPC) xenograft tumors by decreasing ataxia-telangiectasia mutated kinase (ATM) expression[2].

storage

Store at +4°C

References

1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393.

AIM-100 Preparation Products And Raw materials

Raw materials

Preparation Products

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AIM-100 Suppliers

China 79 India 1 The Netherlands 1 United Kingdom 1 United States 14 Global 96
Haoyuan Chemexpress Co., Ltd.
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873305-35-2, AIM-100Related Search:

Sulfanilamide 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

  • AIM-100
  • 5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine
  • AIM 100;AIM100
  • Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-
  • (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine
  • TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer
  • (S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine
  • AIM-100, 10 mM in DMSO
  • 873305-35-2
  • API