AIM-100

ChemicalBook > CAS DataBase List > AIM-100

Product Name: AIM-100
CAS No.: 873305-35-2
Chemical Name: AIM-100
Synonyms: AIM-100;AIM 100;AIM100;(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine;(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine;Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-;TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer
CBNumber: CB72624072
Molecular Formula: C23H21N3O2
Formula Weight: 371.43
MOL File: 873305-35-2.mol

Less

AIM-100 Property

Boiling point:: 552.9±50.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
form: Powder
pka: 4.62±0.40(Predicted)
color: White to yellow

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 50mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 4946
Product name: AIM100
Purity: ≥98%(HPLC)
Packaging: 10
Price: $214
Updated: 2021/12/16

Less

AIM-100 Chemical Properties,Usage,Production

Uses

AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth.

Biological Activity

aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2].

storage

Store at +4°C

References

1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393.

AIM-100 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

AIM-100 Suppliers

China 63 India 1 The Netherlands 1 United Kingdom 1 United States 13 Global 79

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7296
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3253
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30239
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 924
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9772
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10011
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9989
Advantage: 58

Jilin Shengchuang Biotechnology Co., LTD

Tel: 19975838191
Email: 396921152@qq.com
Country: China
ProdList: 166
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29979
Advantage: 58

Auonsi (Shanghai) Biology Technology Co., Ltd.

Tel: 400-1107768 15058188853
Fax: 0571-88150696
Email: 478133536@qq.com
Country: China
ProdList: 8552
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Jilin Shengchuang Biotechnology Co., LTD

Tel: 13251734045
Email: 396921152@qq.com
Country: China
ProdList: 450
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10238
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32957
Advantage: 60

Rhenbo (Shanghai) Biochemical Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6333
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1471
Advantage: 58

Shanghai Yuqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 847627550@qq.com
Country: CHINA
ProdList: 6087
Advantage: 58

Shanghai Qincheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shqcsw01@163.com
Country: CHINA
ProdList: 6367
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Shanghai Jingke Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jingkehuaxue@163.com
Country: CHINA
ProdList: 6972
Advantage: 58

873305-35-2, AIM-100Related Search:

Sulfanilamide 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

AIM-100

5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

AIM 100;AIM100

Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-

(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer

(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine

873305-35-2

API