BNC105

Product Name: BNC105
CAS No.: 945771-74-4
Chemical Name: BNC105
Synonyms: BNC105;CS-2127;BNC105, 10 mM in DMSO;inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin;6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol;2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan;(7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone;Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-
CBNumber: CB72627624
Molecular Formula: C20H20O7
Formula Weight: 372.37
MOL File: 945771-74-4.mol

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BNC105 Property

Melting point:: 156-158 °C(Solv: methanol (67-56-1))
Boiling point:: 529.3±50.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:25.0(Max Conc. mg/mL);67.14(Max Conc. mM)
form: A solid
pka: 6.60±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4191
Product name: BNC105
Purity: 99.49%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-4191
Product name: BNC105
Purity: 99.49%
Packaging: 5mg
Price: $330
Updated: 2021/12/16

Crysdot

Product number: CD31000118
Product name: BNC105
Purity: 98+%
Packaging: 10mg
Price: $347
Updated: 2021/12/16

Crysdot

Product number: CD31000118
Product name: BNC105
Purity: 98+%
Packaging: 5mg
Price: $243
Updated: 2021/12/16

Crysdot

Product number: CD31000118
Product name: BNC105
Purity: 98+%
Packaging: 50mg
Price: $1042
Updated: 2021/12/16

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BNC105 Chemical Properties,Usage,Production

Uses

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

References

[1] Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. DOI:10.1021/jm200454y
[2] Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. DOI:10.1158/1535-7163.MCT-09-0815
[3] Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60. DOI:10.4161/15384047.2014.956605

BNC105 Preparation Products And Raw materials

Raw materials

Preparation Products

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BNC105 Suppliers

China 58 United States 7 Global 65

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
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Musechem

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Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
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Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
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Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

945771-74-4, BNC105Related Search:

BNC105

2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

CS-2127

Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-

(7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone

inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin

6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol

BNC105, 10 mM in DMSO

945771-74-4