ChemicalBook > CAS DataBase List > CZC24832

CZC24832

Product Name: CZC24832
CAS No.: 1159824-67-5
Chemical Name: CZC24832
Synonyms: CS-957;CZC24832;CZC24832 ，S7018;CZC24832 USP/EP/BP;CZC 24832;CZC-24832;CZC24832, 10 mM in DMSO;5-(2-amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide;5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide;5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-(2-amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-
CBNumber: CB72627745
Molecular Formula: C15H17FN6O2S
Formula Weight: 364.4
MOL File: 1159824-67-5.mol

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CZC24832 Property

Density: 1.51
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥6.07 mg/mL in DMSO with gentle warming
form: solid
pka: 10.29±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1214
Product name: CZC24832
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $128
Updated: 2025/07/31

Cayman Chemical

Product number: 14307
Product name: CZC-24832
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 14307
Product name: CZC-24832
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 14307
Product name: CZC-24832
Purity: ≥98%
Packaging: 25mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 14307
Product name: CZC-24832
Purity: ≥98%
Packaging: 50mg
Price: $778
Updated: 2024/03/01

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CZC24832 Chemical Properties,Usage,Production

Uses

CZC24832 is a selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitor. CZC24832 regulates interleukin-17-producing T helper cell (TH17) differentiation by PI3Kγ thus making CZC24832 a potential treatment for inflammatory and autoimmune diseases.

Biological Activity

CZC24832 is a potent and selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with Kd app of 19 nM. CZC24832 is said to be the first selective PI3Kγ inhibitor with efficacy in in vitro and in vivo models of inflammation. CZC24832 strongly inhibited T-cell interleukin 17A (IL-17A) production by inhibiting expression of retinoic acid receptor–related orphan receptor γt (RORγt), a transcription factor th at drives TH17 differentiation, showing a new role for PI3Kγ.

in vivo

CZC24832 shows suitable pharmacokinetic properties including low clearance (0.84 L per h per kg body weight) and high oral bioavailability (37%), thus allowing further characterization of the inhibitor in rodent models of inflammation. In an IL-8-dependent air pouch model, CZC24832 shows a dose-dependent reduction of granulocyte recruitment (80% inhibition at 10 mg per kg body weight) consistent with the degree of inhibition observed in PI3Kγ-null mice. Mice treated orally with 10 mg CZC24832 per kg body weight twice per day show a substantial decrease of bone and cartilage destruction (53% reduction by histopathological analysis) as well as of overall clinical parameters (38% reduction)^[1].

IC 50

PI3Kγ: 27 nM (IC₅₀); PI3Kβ: 1.1 μM (IC₅₀); PI3Kδ: 8.194 μM (IC₅₀)

CZC24832 Preparation Products And Raw materials

Raw materials

Preparation Products

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CZC24832 Suppliers

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View Lastest Price from CZC24832 manufacturers

Career Henan Chemical Co

Product: CZC24832 1159824-67-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

1159824-67-5, CZC24832Related Search:

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CZC24832

5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide

3-Pyridinesulfonamide, 5-(2-amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-

5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide CZC 24832

CZC 24832 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide

5-(2-amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide

CZC 24832;CZC-24832

CS-957

5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide

CZC24832 USP/EP/BP

CZC24832, 10 mM in DMSO

CZC24832 ，S7018

1159824-67-5

C15H17FN6O2S

Akt

mTOR

PI3K

Inhibitors

PI3K/Akt/mTOR