WZ4003

Product Name: WZ4003
CAS No.: 1214265-58-3
Chemical Name: WZ4003
Synonyms: WZ4003;CS-1174;WZ 4003;WZ4003;N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide;N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide;Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-
CBNumber: CB92707353
Molecular Formula: C25H29ClN6O3
Formula Weight: 496.99
MOL File: 1214265-58-3.mol

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WZ4003 Property

Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming
form: powder
pka: 14.27±0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1445
Product name: WZ4003
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $89.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1445
Product name: WZ4003
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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WZ4003 Chemical Properties,Usage,Production

Uses

WZ4003 is a highly specific protein kinase inhibitor of NUAK kinases.

Biological Activity

wz4003 is a potent and selective inhibitor of nuak1 and nuak2 with ic50 values of 20 and 100 nm, respectively [1].nuak family snf1-like kinase-1 (nuak1) and the related nuak2 belong to the amp-activated protein kinase (ampk) family and are activated by liver kinase b1 (lkb1) tumour suppressor protein kinase [1].wz4003 is a potent and selective nuak1/2 inhibitor. in hek-293 cells, wz4003 inhibited the phosphorylation of myosin phosphate-targeting subunit 1 (mypt1), which was phosphorylated by nuak1 at ser445. in hek-293 cells overexpressing inhibitor-resistant nuak1[a195t], wz4003 didn’t inhibit the phosphorylation of mypt1 at ser445. in mouse embryonic fibroblasts (mefs), wz4003 significantly inhibited migration in a wound-healing assay and inhibited mefs proliferation. in a cell invasion assay, wz4003 inhibited the invasive potential of u2os cells [1]. in u2os cells, wz4003 (10 μm) inhibited phosphorylation of mypt1 and reduced the cells in s-phase by 50%. also, wz4003 prevented cells from entering into mitosis [2].

Biochem/physiol Actions

WZ4003 helps to repress the migration of cells. It also prevents cell proliferation.

storage

Store at -20°C

References

[1]. banerjee s, buhrlage sj, huang ht, et al. characterization of wz4003 and hth-01-015 as selective inhibitors of the lkb1-tumour-suppressor-activated nuak kinases. biochem j, 2014, 457(1): 215-225.
[2]. banerjee s, zagórska a, deak m, et al. interplay between polo kinase, lkb1-activated nuak1 kinase, pp1βmypt1 phosphatase complex and the scfβtrcp e3 ubiquitin ligase. biochem j, 2014, 461(2): 233-245.

WZ4003 Preparation Products And Raw materials

Raw materials

Preparation Products

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WZ4003 Suppliers

China 79 India 2 The Netherlands 1 United Kingdom 2 United States 14 Global 98

Shanghai Boyle Chemical Co., Ltd.

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BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Email: info@chemexpress.com
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UHN Shanghai Research & Development Co., Ltd.

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Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
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MedChemexpress LLC

Tel: 021-58955995
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Country: United States
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Nanjing Sunlida Biological Technology Co., Ltd.

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Fax: 025-57019371
Email: sales@sunlidabio.com
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TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
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Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
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Country: China
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View Lastest Price from WZ4003 manufacturers

Career Henan Chemical Co

Product: WZ4003 1214265-58-3
Price: US $0.10/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1g,10g,1kg
Release date: 2020-01-10

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Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-

WZ4003

N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide

WZ 4003;WZ4003

CS-1174

N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide

1214265-58-3

C25H29ClN6O3

Inhibitors