WZ3146

Product Name: WZ3146
CAS No.: 1214265-56-1
Chemical Name: WZ3146
Synonyms: WZ3416;WZ3146;mz3146;CS-525;MZ-3146;WZ 3146;WZ-3146;WZ3146 USP/EP/BP;WZ3146;WZ3146; WZ 3146;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid
CBNumber: CB82500940
Molecular Formula: C24H25ClN6O2
Formula Weight: 464.95
MOL File: 1214265-56-1.mol

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WZ3146 Property

Density: 1.318
storage temp.: Store at -20°C
solubility: ≥23.25 mg/mL in DMSO with gentle warming
form: solid
pka: 12.78±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 50mg
Price: $941
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 10mg
Price: $341
Updated: 2024/03/01

AK Scientific

Product number: X7481
Product name: N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
Packaging: 10mg
Price: $478
Updated: 2021/12/16

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WZ3146 Chemical Properties,Usage,Production

Uses

WZ3146 is an irreversiblely inhibitor against EGFR T790M.

Definition

ChEBI: N-[3-[[5-chloro-2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide is a member of piperazines.

Biological Activity

wz3146 is a novel, irreversible inhibitor that specifically inhibits phosphorylation of egfr(l858r0) and egfr(e746_a750) with ic50 values of 2nm each.wz3146 has been reported to inhibit the phosphorylation of egfr in the non–small-cell lung cancer (nsclc) cell lines [1]. wz3146 shows to suppress the growth of egfr t790m containing cell lines. besides, analysis of recombinant egfr t790m kinase incubated with wz3146 by electrospray mass spectrometry revealed stoichiometric addition of one inhibitor molecule to the protein. analysis of a pepsin digest of the modified protein by tandem ms identified cys 797 as the site of modification thus verifying covalent bond formation between wz3146 and egfr [2].

target

EGFR(L858R)

References

[1] thanyanan reungwetwattana, saravut j. weroha, julian r. molina. oncogenic pathways, molecularly targeted therapies, and highlighted

WZ3146 Preparation Products And Raw materials

Raw materials

Preparation Products

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WZ3146 Suppliers

China 80 United States 15 Global 95

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-58190570 15863796298
Email: 2310993908@qq.com
Country: China
ProdList: 1296
Advantage: 58

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View Lastest Price from WZ3146 manufacturers

Career Henan Chemical Co

Product: WZ3146 1214265-56-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%MIN
Supply Ability: ASK
Release date: 2019-12-25

1214265-56-1, WZ3146Related Search:

WZB117 WZ4003 N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZ4002 WZ4141R WZ4141 Selumetinib Tideglusib WZ8040 PD184352 (CI-1040) Carfilzomib Rapamycin

WZ3416

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid

WZ3146;WZ3146; WZ 3146

WZ3146

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide

mz3146

MZ-3146

CS-525

N-{3-[(5-Chloro-2-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)oxy]phenyl}acrylamide

WZ 3146;WZ-3146

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-

WZ3146 USP/EP/BP

1214265-56-1

Inhibitors