WZ3146
- Product Name
- WZ3146
- CAS No.
- 1214265-56-1
- Chemical Name
- WZ3146
- Synonyms
- WZ3416;WZ3146;mz3146;CS-525;MZ-3146;WZ 3146;WZ-3146;WZ3146 USP/EP/BP;WZ3146;WZ3146; WZ 3146;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid
- CBNumber
- CB82500940
- Molecular Formula
- C24H25ClN6O2
- Formula Weight
- 464.95
- MOL File
- 1214265-56-1.mol
WZ3146 Property
- Density
- 1.318
- storage temp.
- Store at -20°C
- solubility
- ≥23.25 mg/mL in DMSO with gentle warming
- form
- solid
- pka
- 12.78±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 23440
- Product name
- WZ3146
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23440
- Product name
- WZ3146
- Packaging
- 50mg
- Price
- $941
- Updated
- 2024/03/01
- Product number
- 23440
- Product name
- WZ3146
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 23440
- Product name
- WZ3146
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- X7481
- Product name
- N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
- Packaging
- 10mg
- Price
- $478
- Updated
- 2021/12/16
WZ3146 Chemical Properties,Usage,Production
Uses
WZ3146 is an irreversiblely inhibitor against EGFR T790M.
Definition
ChEBI: N-[3-[[5-chloro-2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide is a member of piperazines.
Biological Activity
wz3146 is a novel, irreversible inhibitor that specifically inhibits phosphorylation of egfr(l858r0) and egfr(e746_a750) with ic50 values of 2nm each.wz3146 has been reported to inhibit the phosphorylation of egfr in the non–small-cell lung cancer (nsclc) cell lines [1]. wz3146 shows to suppress the growth of egfr t790m containing cell lines. besides, analysis of recombinant egfr t790m kinase incubated with wz3146 by electrospray mass spectrometry revealed stoichiometric addition of one inhibitor molecule to the protein. analysis of a pepsin digest of the modified protein by tandem ms identified cys 797 as the site of modification thus verifying covalent bond formation between wz3146 and egfr [2].
target
EGFR(L858R)
References
[1] thanyanan reungwetwattana, saravut j. weroha, julian r. molina. oncogenic pathways, molecularly targeted therapies, and highlighted
WZ3146 Preparation Products And Raw materials
Raw materials
Preparation Products
WZ3146 Suppliers
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View Lastest Price from WZ3146 manufacturers
- Product
- WZ3146 1214265-56-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2019-12-25