WZ8040

Product Name: WZ8040
CAS No.: 1214265-57-2
Chemical Name: WZ8040
Synonyms: CS-471;WZ8040;WZ-8040;WZ 8040;WZ8040 USP/EP/BP;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040
CBNumber: CB22501011
Molecular Formula: C24H25ClN6OS
Formula Weight: 481.01
MOL File: 1214265-57-2.mol

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WZ8040 Property

Density: 1.37
storage temp.: Store at -20°C
solubility: ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 12.94±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 25mg
Price: $645
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 50mg
Price: $1139
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 10mg
Price: $290
Updated: 2024/03/01

ApexBio Technology

Product number: A1393
Product name: WZ8040
Packaging: 25mg
Price: $360
Updated: 2021/12/16

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WZ8040 Chemical Properties,Usage,Production

Description

WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC₅₀ values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFR^{Del E746_A750} and EGFR^L858R mutations conferring gefitinib sensitivity and the EGFR^{Del E746_A750/T790M} mutation conferring gefitinib resistance (IC₅₀s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC₅₀ = 1,820 nM in HN11 cells) but also inhibits ERBB2^{Ins G776V,C} and wild-type ERBB2 (IC₅₀s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFR^{Del E746_A750} mutation and gefitinib-resistant PC-9 GR cells harboring the EGFR^T790M resistant allele (EC₅₀s = 6 and 8 nM, respectively).

Uses

WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).

target

EGFR T790M

References

[1] zhou w1, ercan d, chen l, yun ch, li d, capelletti m, cortot ab, chirieac l, iacob re, padera r, engen jr, wong kk, eck mj, gray ns, jänne pa. novel mutant-selective egfr kinase inhibitors against egfr t790m. nature. 2009 dec 24;462(7276):1070-4. doi: 10.1038/nature08622.

WZ8040 Preparation Products And Raw materials

Raw materials

Preparation Products

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WZ8040 Suppliers

China 75 United States 14 Global 89

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
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Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
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HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
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Email: info@yuhaochemical.com
Country: China
ProdList: 2031
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Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-58761217 15863796298
Email: boluodechem_chem@163.com
Country: China
ProdList: 332
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WZ8040

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

CS-471

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040

N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami

WZ-8040;WZ 8040

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-

WZ8040 USP/EP/BP

1214265-57-2

Inhibitors