WZ8040

ChemicalBook > CAS DataBase List > WZ8040

Product Name: WZ8040
CAS No.: 1214265-57-2
Chemical Name: WZ8040
Synonyms: CS-471;WZ8040;WZ-8040;WZ 8040;WZ8040 USP/EP/BP;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040
CBNumber: CB22501011
Molecular Formula: C24H25ClN6OS
Formula Weight: 481.01
MOL File: 1214265-57-2.mol

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WZ8040 Property

Density: 1.37
storage temp.: Store at -20°C
solubility: ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 12.94±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 25mg
Price: $645
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 50mg
Price: $1139
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 30062
Product name: WZ8040
Packaging: 10mg
Price: $290
Updated: 2024/03/01

ApexBio Technology

Product number: A1393
Product name: WZ8040
Packaging: 25mg
Price: $360
Updated: 2021/12/16

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WZ8040 Chemical Properties,Usage,Production

Description

WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC₅₀ values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFR^{Del E746_A750} and EGFR^L858R mutations conferring gefitinib sensitivity and the EGFR^{Del E746_A750/T790M} mutation conferring gefitinib resistance (IC₅₀s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC₅₀ = 1,820 nM in HN11 cells) but also inhibits ERBB2^{Ins G776V,C} and wild-type ERBB2 (IC₅₀s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFR^{Del E746_A750} mutation and gefitinib-resistant PC-9 GR cells harboring the EGFR^T790M resistant allele (EC₅₀s = 6 and 8 nM, respectively).

Uses

WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).

target

EGFR T790M

References

[1] zhou w1, ercan d, chen l, yun ch, li d, capelletti m, cortot ab, chirieac l, iacob re, padera r, engen jr, wong kk, eck mj, gray ns, jänne pa. novel mutant-selective egfr kinase inhibitors against egfr t790m. nature. 2009 dec 24;462(7276):1070-4. doi: 10.1038/nature08622.

WZ8040 Preparation Products And Raw materials

Raw materials

Preparation Products

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WZ8040 Suppliers

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WZ8040

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

CS-471

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040

N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami

WZ-8040;WZ 8040

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-

WZ8040 USP/EP/BP

1214265-57-2

Inhibitors