GSK 561679A
- Product Name
- GSK 561679A
- CAS No.
- 885220-61-1
- Chemical Name
- GSK 561679A
- Synonyms
- CPD1230;CS-2618;NBI77860;GSK561679;Verucerfont;GSK 561679A;Verucerfont,GSK561679;Verucerfont/GSK561679A;Verucerfont, 10 mM in DMSO;VERUCERFONT; GSK561679; NBI77860
- CBNumber
- CB72627927
- Molecular Formula
- C22H26N6O2
- Formula Weight
- 406.48
- MOL File
- 885220-61-1.mol
GSK 561679A Property
- Density
- 1.29
- storage temp.
- Store at -20°C
- solubility
- DMSO : 86.7 mg/mL (213.29 mM)
- pka
- 4.78±0.40(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1
- InChIKey
- VKHVAUKFLBBZFJ-SFHVURJKSA-N
- SMILES
- C12=C(C3=CC=C(OC)C=C3C)C(C)=NN1C(N[C@H](C1ON=C(C)N=1)CC)=CC(C)=N2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- V125025
- Product name
- Verucerfont
- Packaging
- 1mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-8099
- Product name
- Verucerfont
- Purity
- 98.67%
- Packaging
- 5mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- CS-8099
- Product name
- Verucerfont
- Purity
- 98.67%
- Packaging
- 10mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- API0013931
- Product name
- GSK-561679A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.2
- Updated
- 2021/12/16
- Product number
- CS-8099
- Product name
- Verucerfont
- Purity
- 98.67%
- Packaging
- 50mg
- Price
- $1150
- Updated
- 2021/12/16
GSK 561679A Chemical Properties,Usage,Production
Uses
Verucerfont, is a corticotropin-releasing factor receptor 1 (CRF1) antagonist.
in vivo
Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316?311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailed Post hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6?h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline)[1].
IC 50
CRFR1
GSK 561679A Preparation Products And Raw materials
Raw materials
Preparation Products
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