ChemicalBook > CAS DataBase List > MLN0905
MLN0905
- Product Name
- MLN0905
- CAS No.
- 1228960-69-7
- Chemical Name
- MLN0905
- Synonyms
- CS-1458;MLN0905;AI314412;AI3 14412;AI3-14412;PLK1 Inhibitor;MLN0905 USP/EP/BP;PLK1 INHIBITOR; MLN 0905; MLN-0905;2-[[5-[3-(Dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- 6H-pyrimido[5,4-d][1]benzazepine-6-thione;2-((5-(3-(Dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-9-(trifluoromethyl)-5,7-dihydro-6H-benzo[b]pyrimido[4,5-d]azepine-6-thione
- CBNumber
- CB72628151
- Molecular Formula
- C24H25F3N6S
- Formula Weight
- 486.56
- MOL File
- 1228960-69-7.mol
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MLN0905 Property
- Boiling point:
- 624.4±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Store at -20°C
- solubility
- ≥24.35 mg/mL in DMSO
- form
- solid
- pka
- 9.80±0.20(Predicted)
- color
- Off-white to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Usbiological
- Product number
- 474138
- Product name
- MLN0905
- Packaging
- 100mg
- Price
- $1848
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb181293
- Product name
- MLN0905
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1876.8
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon1910
- Product name
- MLN0905
- Purity
- 98%
- Packaging
- 2mg
- Price
- $104.5
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb181293
- Product name
- MLN0905
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $3728.1
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A8680
- Product name
- MLN0905
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
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MLN0905 Chemical Properties,Usage,Production
Biological Activity
mln0905 is a potent inhibitor of plk1 with ic50 value ranges from 3 to 24 nm [1].polo-like kinase 1 (plk1) is a family of conserved serine/threonine kinases and plays an important role in regulating cell cycle. it has been revealed that plk1 drives cell cycle progression by triggerting g2/m transition and is considered as a pro-oncogene which overexpressed in tumor cells [2].mln0905 is a selective plk1 inhibitor and has similar effect as rnai hnockdown. when tested with ht-29 cells, mln0905 treatment significantly increased phish3 expression which indicated that cells were arrested in g2/m phase by inhibiting plk1 expression [1].in mouse model with human diffuse large b-cell lymphoma (dlbcl) cell line ocily-19 subcutaneous xenograft, co-administration of mln0905 and rituximab markedly reduced tumor volume and increased survival time through inhibiting plk1 which resulted in mitotic arrest [1]. and the same result was achieved when using nude mice model with human colon tumor ht29 xenograft, mln0905 treatment significantly inhibited tumor growth or progression [3].
target
PLK1
References
[1]. shi, j.q., et al., mln0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large b-cell lymphoma. mol cancer ther, 2012. 11(9): p. 2045-53.
[2]. espeut, j., et al., natural loss of mps1 kinase in nematodes uncovers a role for polo-like kinase 1 in spindle checkpoint initiation. cell rep, 2015.
[3]. duffey, m.o., et al., discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (mln0905). j med chem, 2012. 55(1): p. 197-208.
MLN0905 Preparation Products And Raw materials
Raw materials
Preparation Products
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