ChemicalBook > CAS DataBase List > MLN0905

MLN0905

Product Name
MLN0905
CAS No.
1228960-69-7
Chemical Name
MLN0905
Synonyms
CS-1458;MLN0905;AI314412;AI3 14412;AI3-14412;PLK1 Inhibitor;MLN0905 USP/EP/BP;PLK1 INHIBITOR; MLN 0905; MLN-0905;2-[[5-[3-(Dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- 6H-pyrimido[5,4-d][1]benzazepine-6-thione;2-((5-(3-(Dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-9-(trifluoromethyl)-5,7-dihydro-6H-benzo[b]pyrimido[4,5-d]azepine-6-thione
CBNumber
CB72628151
Molecular Formula
C24H25F3N6S
Formula Weight
486.56
MOL File
1228960-69-7.mol
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MLN0905 Property

Boiling point:
624.4±65.0 °C(Predicted)
Density 
1.37±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C
solubility 
≥24.35 mg/mL in DMSO
form 
solid
pka
9.80±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological
Product number
474138
Product name
MLN0905
Packaging
100mg
Price
$1848
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181293
Product name
MLN0905
Purity
>98%
Packaging
250mg
Price
$1876.8
Updated
2021/12/16
Axon Medchem
Product number
Axon1910
Product name
MLN0905
Purity
98%
Packaging
2mg
Price
$104.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181293
Product name
MLN0905
Purity
>98%
Packaging
1000mg
Price
$3728.1
Updated
2021/12/16
ApexBio Technology
Product number
A8680
Product name
MLN0905
Packaging
5mg
Price
$210
Updated
2021/12/16
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MLN0905 Chemical Properties,Usage,Production

Biological Activity

mln0905 is a potent inhibitor of plk1 with ic50 value ranges from 3 to 24 nm [1].polo-like kinase 1 (plk1) is a family of conserved serine/threonine kinases and plays an important role in regulating cell cycle. it has been revealed that plk1 drives cell cycle progression by triggerting g2/m transition and is considered as a pro-oncogene which overexpressed in tumor cells [2].mln0905 is a selective plk1 inhibitor and has similar effect as rnai hnockdown. when tested with ht-29 cells, mln0905 treatment significantly increased phish3 expression which indicated that cells were arrested in g2/m phase by inhibiting plk1 expression [1].in mouse model with human diffuse large b-cell lymphoma (dlbcl) cell line ocily-19 subcutaneous xenograft, co-administration of mln0905 and rituximab markedly reduced tumor volume and increased survival time through inhibiting plk1 which resulted in mitotic arrest [1]. and the same result was achieved when using nude mice model with human colon tumor ht29 xenograft, mln0905 treatment significantly inhibited tumor growth or progression [3].

target

PLK1

References

[1]. shi, j.q., et al., mln0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large b-cell lymphoma. mol cancer ther, 2012. 11(9): p. 2045-53.
[2]. espeut, j., et al., natural loss of mps1 kinase in nematodes uncovers a role for polo-like kinase 1 in spindle checkpoint initiation. cell rep, 2015.
[3]. duffey, m.o., et al., discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (mln0905). j med chem, 2012. 55(1): p. 197-208.

MLN0905 Preparation Products And Raw materials

Raw materials

Preparation Products

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MLN0905 Suppliers

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1228960-69-7, MLN0905Related Search:

Binimetinib ARRY-424704, ARRY-704 BKM120 (NVP-BKM120, Buparlisib) 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid NVP-BVU 972 Tozasertib R428 Nutlin 3a 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide BMS-794833 RO3280 Nintedanib GSK461364 5-Azacytidine NMS-P937 (NMS1286937) Volasertib (BI 6727)

  • MLN0905
  • 2-[[5-[3-(Dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- 6H-pyrimido[5,4-d][1]benzazepine-6-thione
  • 6H-Pyrimido[5,4-d][1]benzazepine-6-thione, 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-
  • 2-[[5-[3-(Dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- 6H-pyrimido[5,4-d][1]benzazepine-6-thione MLN0905
  • MLN0905 2-[[5-[3-(Dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)- 6H-pyrimido[5,4-d][1]benzazepine-6-thione
  • PLK1 Inhibitor
  • CS-1458
  • PLK1 INHIBITOR; MLN 0905; MLN-0905
  • MLN0905 USP/EP/BP
  • AI3 14412
  • AI314412
  • AI3-14412
  • 2-((5-(3-(Dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-9-(trifluoromethyl)-5,7-dihydro-6H-benzo[b]pyrimido[4,5-d]azepine-6-thione
  • 1228960-69-7
  • C24H25F3N6S
  • API
  • Inhibitors