VidofludiMus

Product Name: VidofludiMus
CAS No.: 717824-30-1
Chemical Name: VidofludiMus
Synonyms: 4SC-101;CS-1196;SC12267);VidofludiMus;VidofludiMus(4SC-101;VIDOFLUDIMUS(4SC-101; SC12267);4SC-101; SC12267;4SC101;4SC 101;2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
CBNumber: CB72628520
Molecular Formula: C20H18FNO4
Formula Weight: 355.36
MOL File: 717824-30-1.mol

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VidofludiMus Property

Boiling point:: 567.5±50.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO
form: solid
pka: 4?+-.0.20(Predicted)
color: Light yellow to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18377
Product name: Vidofludimus
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 18377
Product name: Vidofludimus
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 18377
Product name: Vidofludimus
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 18377
Product name: Vidofludimus
Purity: ≥98%
Packaging: 25mg
Price: $485
Updated: 2024/03/01

TRC

Product number: V305033
Product name: Vidofludimus
Packaging: 25mg
Price: $330
Updated: 2021/12/16

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VidofludiMus Chemical Properties,Usage,Production

Uses

Vidofludimus is an immunosuppressive drug that inhibits dihydroorotate dehydrogenase (DHODH) and the expression of proinflammatory cytokines including interleukin-17 (IL17A and IL17F) and interferon-gamma.

Biological Activity

vidofludimus (4sc-101, sc12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (dhodh) with an ic50 value of 134nmol/l for human dhodh [1].vidofludimus (4sc-101, sc12267) has been reported to dose-dependently inhibit dhodh in an in vitro enzyme assay with ic50 values of 0.134μmol/l, 1.29μmol/l, 10.6μmol/l and 12.9μmol/l in human dhodh, rat dhodh, mouse dhodh and human pbmc, respectively [1]. in addition, vidofludimus has shown the inhibition of proliferation in phytohemagglutinin-induced lymphocytes with an ic50 value of ~13μmol/l. moreover, vidofludimus has been revealed to concentration-dependently inhibit phytohemagglutinin-stimulated interukin-17 secretion from human peripgeral blppd mononuclear cell lines (pbmcs) with an ic50 value of 6 μmol/l [2].

References

[1] kulkarni op1, sayyed sg, kantner c, ryu m, schnurr m, sárdy m, leban j, jankowsky r, ammendola a, doblhofer r, anders hj. 4sc-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in mrl-(fas) lpr mice. am j pathol. 2010 jun;176(6):2840-7.
[2] fitzpatrick lr1, deml l, hofmann c, small js, groeppel m, hamm s, lemstra s, leban j, ammendola a. 4sc-101, a novel immunosuppressive drug, inhibits il-17 and attenuates colitis in two murine models of inflammatory bowel disease. inflamm bowel dis. 2010 oct;16(10):1763-77.

VidofludiMus Preparation Products And Raw materials

Raw materials

Preparation Products

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VidofludiMus Suppliers

China 79 India 1 The Netherlands 1 United Kingdom 1 United States 15 Global 97

MedChemexpress LLC

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View Lastest Price from VidofludiMus manufacturers

airuikechemical co., ltd.

Product: Vidofludimus 717824-30-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-07

Career Henan Chemical Co

Product: VidofludiMus 717824-30-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

717824-30-1, VidofludiMusRelated Search:

VidofludiMus

SC12267)

VidofludiMus(4SC-101

VIDOFLUDIMUS(4SC-101; SC12267)

2-[[(3-Fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid

2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid

2-[(3-fluoro-3'-methoxybiphenyl-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid Vidofludimus(4SC-101

4SC-101

CS-1196

4SC-101; SC12267;4SC101;4SC 101

1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-

2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid

DHODH,fatty liver,Inhibitor,Vidofludimus,Dihydroorotate Dehydrogenase,dihydroorotate dehydrogenase (DHODH),oral,Interleukin Related,SC-12267,FXR,NR1H4,non-alcoholic fatty liver disease (NAFLD),inflammatory bowel disease (IBD),immunomodulatory,farnesoid X receptor (FXR),inhibit,SC 12267

2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid

2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-ene-1-carboxylic acid

717824-30-1

7178240-30-1

API

Inhibitors