ChemicalBook > CAS DataBase List > Methyl 1-Methyl-1H-indole-4-carboxylate

Methyl 1-Methyl-1H-indole-4-carboxylate

Product Name
Methyl 1-Methyl-1H-indole-4-carboxylate
CAS No.
1444-12-8
Chemical Name
Methyl 1-Methyl-1H-indole-4-carboxylate
Synonyms
Methyl 1-Methyl-4-indolecarboxylate;Methyl 1-Methylindole-4-carboxylate;4-(Methoxycarbonyl)-1-methyl-1H-indole;Methyl 1-Methyl-1H-indole-4-carboxylate;1-methyl-1H-Indole-4-carboxylic acid methyl ester;1H-Indole-4-carboxylic acid, 1-methyl-, methyl ester
CBNumber
CB72631610
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
1444-12-8.mol
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Methyl 1-Methyl-1H-indole-4-carboxylate Property

Melting point:
53 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
Boiling point:
320.2±15.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
Light yellow to yellow Crystal
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M338483
Product name
Methyl1-Methyl-1H-indole-4-carboxylate
Packaging
500mg
Price
$175
Updated
2021/12/16
AK Scientific
Product number
V3326
Product name
Methyl1-methylindole-4-carboxylate
Packaging
1g
Price
$168
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-7V
Product name
Methyl 1-methyl-1H-indole-4-carboxylate
Packaging
1g
Price
$332
Updated
2021/12/16
Matrix Scientific
Product number
088400
Product name
Methyl 1-methyl-1H-indole-4-carboxylate
Packaging
1g
Price
$448
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0384686
Product name
METHYL-1-METHYL-1H-INDOLE-4-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$500.06
Updated
2021/12/16
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Methyl 1-Methyl-1H-indole-4-carboxylate Chemical Properties,Usage,Production

Synthesis

39830-66-5

74-88-4

1444-12-8

To a 40 mL reaction vial was added a solution of methyl 1H-indole-4-carboxylate (400 mg, 2.28 mmol, 1.00 equiv) in N,N-dimethylformamide (10 mL). Sodium hydride (275 mg, 6.88 mmol, 3.00 equiv, 60% dispersed in mineral oil) was added in batches at 0 °C. After keeping stirring at 0 °C for 0.5 h, iodomethane (1.298 g, 9.14 mmol, 4.00 eq.) was slowly added dropwise at the same temperature. The reaction mixture was warmed to 25 °C and stirred for 15 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Methyl 1-methyl-4-indolecarboxylate (429 mg, 99%) was obtained as a red oil after concentration under reduced pressure. Mass spectrum (electrospray ionization, m/z): [M+H]+ 190.

References

[1] Patent: WO2017/205296, 2017, A1. Location in patent: Paragraph 78
[2] Patent: US2009/298809, 2009, A1. Location in patent: Page/Page column 17
[3] Heterocycles, 2006, vol. 67, # 2, p. 643 - 653

Methyl 1-Methyl-1H-indole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 1-Methyl-1H-indole-4-carboxylate Suppliers

China 23 India 1 United Kingdom 1 United States 5 Global 30
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1444-12-8, Methyl 1-Methyl-1H-indole-4-carboxylateRelated Search:

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  • Methyl 1-Methyl-4-indolecarboxylate
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