ChemicalBook > CAS DataBase List > 2-Chloro-3-iodo-5-nitropyridine

2-Chloro-3-iodo-5-nitropyridine

Product Name
2-Chloro-3-iodo-5-nitropyridine
CAS No.
25391-60-0
Chemical Name
2-Chloro-3-iodo-5-nitropyridine
Synonyms
2-Chloro-3-iodo-5-nitropyridine;Pyridine, 2-chloro-3-iodo-5-nitro-
CBNumber
CB72638053
Molecular Formula
C5H2ClIN2O2
Formula Weight
284.44
MOL File
25391-60-0.mol
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2-Chloro-3-iodo-5-nitropyridine Property

Melting point:
102-106°C
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
Appearance
Off-white to gray Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
714828
Product name
2-Chloro-3-iodo-5-nitropyridine
Purity
97%
Packaging
1g
Price
$101
Updated
2023/01/07
TRC
Product number
C368848
Product name
2-Chloro-3-iodo-5-nitropyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C368848
Product name
2-Chloro-3-iodo-5-nitropyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C368848
Product name
2-Chloro-3-iodo-5-nitropyridine
Packaging
500mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC55786
Product name
2-Chloro-3-iodo-5-nitropyridine
Packaging
250mg
Price
$80
Updated
2021/12/16
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2-Chloro-3-iodo-5-nitropyridine Chemical Properties,Usage,Production

Synthesis

25391-58-6

25391-60-0

General procedure for the synthesis of 2-chloro-3-iodo-5-nitropyridine from 3-iodo-2-hydroxy-5-nitropyridine: 1. a mixture of 3-iodo-5-nitropyridin-2-ol (37.60 mmol, 10 g), phosphorus trichloride (POCl3, 86.47 mmol, 7.94 mL), and phosphorus pentachloride (PCl5, 48.87 mmol, 10.2 g) was heated under argon protection for 45 min at 140 °C. 2. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and extracted with dichloromethane (DCM). 3. The organic phase was washed sequentially with water, aqueous sodium bicarbonate (NaHCO3) and brine. 4. The solvent was removed by evaporation and the crude product was purified by column chromatography on silica gel (SiO2), eluting with a hexane/dichloromethane solvent mixture to afford the target product, 2-chloro-3-iodo-5-nitropyridine (7.32 g, 69% yield). 5. The structure of the product was determined by 1H NPD analysis. 5. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 8.90 (s, 1H), 9.19 (s, 1H). Note: Repeat steps have been combined to ensure conciseness and accuracy of experimental steps.

References

[1] Australian Journal of Chemistry, 2008, vol. 61, # 6, p. 438 - 445
[2] Patent: EP2599771, 2013, A1. Location in patent: Paragraph 0505
[3] Patent: WO2015/73528, 2015, A1. Location in patent: Page/Page column 191
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 13, p. 2841 - 2849
[5] Patent: WO2009/21696, 2009, A1. Location in patent: Page/Page column 37-38; 41; 69

2-Chloro-3-iodo-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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25391-60-0, 2-Chloro-3-iodo-5-nitropyridineRelated Search:

2-Nitrocinnamic acid

  • 2-Chloro-3-iodo-5-nitropyridine
  • Pyridine, 2-chloro-3-iodo-5-nitro-
  • 25391-60-0
  • alkyl Iodine|alkyl chloride |nitro-compound