2-Chloro-3-iodo-5-nitropyridine

Product Name: 2-Chloro-3-iodo-5-nitropyridine
CAS No.: 25391-60-0
Chemical Name: 2-Chloro-3-iodo-5-nitropyridine
Synonyms: 2-Chloro-3-iodo-5-nitropyridine;Pyridine, 2-chloro-3-iodo-5-nitro-
CBNumber: CB72638053
Molecular Formula: C5H2ClIN2O2
Formula Weight: 284.44
MOL File: 25391-60-0.mol

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2-Chloro-3-iodo-5-nitropyridine Property

Melting point:: 102-106°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
Appearance: Off-white to gray Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 714828
Product name: 2-Chloro-3-iodo-5-nitropyridine
Purity: 97%
Packaging: 1g
Price: $101
Updated: 2023/01/07

TRC

Product number: C368848
Product name: 2-Chloro-3-iodo-5-nitropyridine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

TRC

Product number: C368848
Product name: 2-Chloro-3-iodo-5-nitropyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C368848
Product name: 2-Chloro-3-iodo-5-nitropyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC55786
Product name: 2-Chloro-3-iodo-5-nitropyridine
Packaging: 500mg
Price: $125
Updated: 2021/12/16

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2-Chloro-3-iodo-5-nitropyridine Chemical Properties,Usage,Production

Synthesis

25391-58-6

25391-60-0

General procedure for the synthesis of 2-chloro-3-iodo-5-nitropyridine from 3-iodo-2-hydroxy-5-nitropyridine: 1. a mixture of 3-iodo-5-nitropyridin-2-ol (37.60 mmol, 10 g), phosphorus trichloride (POCl3, 86.47 mmol, 7.94 mL), and phosphorus pentachloride (PCl5, 48.87 mmol, 10.2 g) was heated under argon protection for 45 min at 140 °C. 2. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and extracted with dichloromethane (DCM). 3. The organic phase was washed sequentially with water, aqueous sodium bicarbonate (NaHCO3) and brine. 4. The solvent was removed by evaporation and the crude product was purified by column chromatography on silica gel (SiO2), eluting with a hexane/dichloromethane solvent mixture to afford the target product, 2-chloro-3-iodo-5-nitropyridine (7.32 g, 69% yield). 5. The structure of the product was determined by 1H NPD analysis. 5. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 8.90 (s, 1H), 9.19 (s, 1H). Note: Repeat steps have been combined to ensure conciseness and accuracy of experimental steps.

References

[1] Australian Journal of Chemistry, 2008, vol. 61, # 6, p. 438 - 445
[2] Patent: EP2599771, 2013, A1. Location in patent: Paragraph 0505
[3] Patent: WO2015/73528, 2015, A1. Location in patent: Page/Page column 191
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 13, p. 2841 - 2849
[5] Patent: WO2009/21696, 2009, A1. Location in patent: Page/Page column 37-38; 41; 69

2-Chloro-3-iodo-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-iodo-5-nitropyridine Suppliers

China 47 India 2 United Kingdom 1 United States 5 Global 55

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25391-60-0

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