CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
- Product Name
- CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
- CAS No.
- 314042-01-8
- Chemical Name
- CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
- Synonyms
- CS-1986;SID57578339;CID-1067700;2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid;CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid;2-[[(Benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid;5H-Thieno[2,3-c]pyran-3-carboxylic acid, 2-[[(benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-;ML282,competitively,CID1067700,brain,Rab7,ML 282,GTPase,Ras,machinery,Ras-related,CID-1067700,ML-282,inhibit,CSR,Inhibitor,CID 1067700
- CBNumber
- CB72642195
- Molecular Formula
- C18H18N2O4S2
- Formula Weight
- 390.48
- MOL File
- 314042-01-8.mol
CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid Property
- Density
- 1.410±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 4.25±0.40(Predicted)
- form
- powder
- color
- white to light brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0545
- Product name
- CID 1067700
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- SML0545
- Product name
- CID 1067700
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $496
- Updated
- 2024/03/01
- Product number
- 15194
- Product name
- CID 1067700
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 15194
- Product name
- CID 1067700
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 15194
- Product name
- CID 1067700
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $142
- Updated
- 2024/03/01
CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid Chemical Properties,Usage,Production
Description
The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. CID-
Uses
This compound acts as a novel GTPase inhibitor.
Definition
ChEBI: 2-[[benzamido(sulfanylidene)methyl]amino]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid is a thienopyran.
Biochem/physiol Actions
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases that potently binds to Rab7 nucleotide binding site.
References
Agola et al. (2012), A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition; ACS Chem. Biol., 7 1095 Agola et al. (2015), Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein; Methods Mol. Biol., 1298 331 Lam et al. (2016), Small Molecule Inhibition of Rab7 Impairs B Cell Switching and Plasma Cell Survival To Dampen the Autoantibody response in Murine Lupus; J. Immunol., 197 3792 Ghosh et al. (2020), ?-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway; Cell, 183 1520
CID-1067700,2-(3-benzoylthioureido)-5,5-diMethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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