2-CHLORO-N-METHOXY-N-METHYLACETAMIDE

Product Name: 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE
CAS No.: 67442-07-3
Chemical Name: 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE
Synonyms: 100823;EOS-60814;2-Chloro-N-methylacetohydroxamate;2-CHLORO-N-METHOXY-N-METHYLACETAMIDE;N-Methyl-N-methoxy-2-chloroacetamide;N-(Chloroacetyl)-N-methoxymethylamine;AcetaMide, 2-chloro-N-Methoxy-N-Methyl-;2-Chloro-N-methoxy-N-methylacetamide 98%;2-Chloro-N-methoxy-N-methylacetamide,97%;Methyl 2-Chloro-N-methylacetohydroxamate
CBNumber: CB7265277
Molecular Formula: C4H8ClNO2
Formula Weight: 137.56
MOL File: 67442-07-3.mol

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2-CHLORO-N-METHOXY-N-METHYLACETAMIDE Property

Melting point:: 39-41 °C(lit.)
Boiling point:: 94-95 °C
Density: 1.178±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 220 °F
storage temp.: 2-8°C
form: Crystals
color: White to light yellow
Water Solubility: Insoluble in water.
BRN: 1924015
InChI: InChI=1S/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3
InChIKey: SCOJKGRNQDKFRP-UHFFFAOYSA-N
SMILES: C(N(OC)C)(=O)CCl
CAS DataBase Reference: 67442-07-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 23-26-27-28-37/39
WGK Germany: 3
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 362425
Product name: 2-Chloro-N-methoxy-N-methylacetamide
Purity: 98%
Packaging: 5g
Price: $54.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 362425
Product name: 2-Chloro-N-methoxy-N-methylacetamide
Purity: 98%
Packaging: 25g
Price: $230
Updated: 2025/07/31

TCI Chemical

Product number: C2272
Product name: 2-Chloro-N-methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: C2272
Product name: 2-Chloro-N-methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $118
Updated: 2025/07/31

TRC

Product number: C428280
Product name: 2-Chloro-N-methoxy-N-methylacetamide
Packaging: 1g
Price: $75
Updated: 2021/12/16

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2-CHLORO-N-METHOXY-N-METHYLACETAMIDE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystals

Uses

2-Chloro-N-methoxy-N-methylacetamide is used in the preparation of 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related 2-alkyl-4-quinolones having biological activity, 2-(benzo[d]thiazol-2-ylsulfonyl)-N-methoxy-N-methylacetamide and α-chloro-ketone, starting reagent for the one-pot synthesis of 2-heptyl-3-hydroxyl-4(1H)-quinolone (PQS), signaling molecule in the quorum sensing of Pseudomonas aeruginosa.

General Description

2-Chloro-N-methoxy-N-methylacetamide is a Weinreb amide.

Synthesis

6638-79-5

79-04-9

67442-07-3

Example 139 Synthesis of N-methoxy-N-methylchloroacetamide: N,O-dimethylhydroxylamine hydrochloride (200 g, 2.05 mol) was dissolved in tert-butyl methyl ether (2 L), and the solution was slowly added to an aqueous solution of potassium carbonate (624 g, 4.1 mol) (2 L) that was pre-cooled to 0 °C. The reaction mixture was further cooled to -5 °C, followed by the slow dropwise addition of chloroacetyl chloride, controlling the reaction temperature to not exceed 5 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature with continuous vigorous stirring for 3.5 hours. After completion of the reaction, the organic and aqueous phases were separated and the aqueous phase was extracted with tert-butyl methyl ether (3 x 1 L). All organic phases were combined, washed with saturated aqueous sodium chloride solution (2 x 1 L), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was dried under vacuum to give a white solid product (257 g, 92% yield). The product was characterized by the following data: melting point 39-40.5 °C; 1H NMR (CDCl3, 300 MHz) δ 4.24 (s, 2H), 3.74 (s, 3H), 3.22 (s, 3H); mass spectra (CI) m/z 138 (MH+); elemental analysis (C4H8ClNO2) calculated values: C, 34.92; H, 5.86; N, 10.18; measured values. 10.18; measured values: C, 35.06; H, 5.88; N, 10.23.

References

[1] Journal of the American Chemical Society,
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 1077 - 1091
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 27, p. 3917 - 3920
[4] RSC Advances, 2013, vol. 3, # 26, p. 10158 - 10162
[5] Patent: EP1054881, 2008, B1. Location in patent: Page/Page column 57

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-N-METHOXY-N-METHYLACETAMIDE Suppliers

Americas 1 Belgium 3 China 188 Europe 4 France 2 Germany 4 India 8 Japan 4 Switzerland 2 United Kingdom 9 United States 25 Global 250

Sci General Material & Chemical Ltd

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View Lastest Price from 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 10000KGS
Release date: 2025-07-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-11-11

Henan Aochuang Chemical Co.,Ltd.

Product: 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

67442-07-3, 2-CHLORO-N-METHOXY-N-METHYLACETAMIDERelated Search:

O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE N-Methylacetamide N-Methoxy-N-methylacetamide 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE CS 722 1-[3A,11C-DIHYDRO-3H-BENZO[5,6]CHROMENO[4,3-C]ISOXAZOL-1(4H)-YL]-2-CHLORO-1-ETHANONE 2-(CHLOROACETYL)-5-METHYLISOXAZOL-3(2H)-ONE 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE, 98 %

100823

Methyl 2-Chloro-N-methylacetohydroxamate

N-(Chloroacetyl)-N-methoxymethylamine

AcetaMide, 2-chloro-N-Methoxy-N-Methyl-

N-Methyl-N-methoxy-2-chloroacetamide

2-Chloro-N-methoxy-N-methylacetamide,97%

N-(Chloroacetyl)-N-methoxymethylamine, N-(2-Chloroethanoyl)-N-methoxymethylamine

2-Chloro-N-methoxy-N-methylacetamide 98%

2-Chloro-N-methylacetohydroxamate

EOS-60814

2-Chloro-N-methoxy-N-methylacetamide &gt

2-Chloro-<i>N</i>-methoxy-<i>N</i>-methylacetamide

67442-07-3

674442-07-3

67224-07-3

C4H8ClNO2

ClCH2CONOCH3CH3

HALOGEN

Organic Building Blocks

Amides

Building Blocks

Carbonyl Compounds

Halides

Amides

Carbonyl Compounds

Organic Building Blocks