ChemicalBook > CAS DataBase List > 6-BroMo-3,4-dihydroquinazolin-2(1H)-one

6-BroMo-3,4-dihydroquinazolin-2(1H)-one

Product Name
6-BroMo-3,4-dihydroquinazolin-2(1H)-one
CAS No.
1246765-38-7
Chemical Name
6-BroMo-3,4-dihydroquinazolin-2(1H)-one
Synonyms
6-Bromo-3,4-dihydroquinazolin-2(1H);6-Bromo-3,4-dihydro-1H-quizolin-2-one;6-Bromo-3,4-dihydro-1H-quinazolin-2-one;6-BroMo-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 6-bromo-3,4-dihydro-
CBNumber
CB72661154
Molecular Formula
C8H7BrN2O
Formula Weight
227.06
MOL File
1246765-38-7.mol
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6-BroMo-3,4-dihydroquinazolin-2(1H)-one Property

Boiling point:
309.5±42.0 °C(Predicted)
Density 
1.610±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.13±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B997873
Product name
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
3456AJ
Product name
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging
10g
Price
$1508
Updated
2021/12/16
AK Scientific
Product number
3456AJ
Product name
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging
5g
Price
$1021
Updated
2021/12/16
AK Scientific
Product number
3456AJ
Product name
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging
250mg
Price
$177
Updated
2021/12/16
AK Scientific
Product number
3456AJ
Product name
6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging
1g
Price
$373
Updated
2021/12/16
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6-BroMo-3,4-dihydroquinazolin-2(1H)-one Chemical Properties,Usage,Production

Synthesis

771583-12-1

32315-10-9

1246765-38-7

Step 2: Synthesis of 6-bromo-3,4-dihydroquinazolin-2(1H)-one; Triethylamine (0.454 g, 4.5 mmol) was added slowly and dropwise to a solution of tetrahydrofuran (20 mL) containing triphosgene (0.445 g, 1.5 mmol) at 0 °C and under nitrogen protection. After stirring the reaction mixture for 30 minutes, a solution of 2-aminomethyl-4-bromoaniline (0.201 g, 1 mmol) in tetrahydrofuran (10 mL) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with water (15 mL) and the pH was adjusted to 8-9 with 1 M aqueous sodium hydroxide solution.Subsequently, it was extracted three times with ethyl acetate (30 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by recrystallization from a solvent mixture of dichloromethane and ethyl ether to afford 6-bromo-3,4-dihydroquinazolin-2-one (0.13 g, 57.5% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δppm: 9.12 (s, 1H), 7.29 (s, 1H), 7.27 (d, J=8.4 Hz. 1H), 6.87 (s, 1H), 6.70 (d, J=8.4Hz, 1H), 4.28 (s, 2H).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 62
[2] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 2031 - 2036
[3] Patent: US2015/232448, 2015, A1. Location in patent: Paragraph 0048

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BroMo-3,4-dihydroquinazolin-2(1H)-one Suppliers

China 37 India 1 United States 6 Global 44
Accela ChemBio Inc.
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+1-858-6993322
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Synthonix Inc
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Matrix Scientific
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View Lastest Price from 6-BroMo-3,4-dihydroquinazolin-2(1H)-one manufacturers

Career Henan Chemical Co
Product
6-BroMo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09
Career Henan Chemical Co
Product
6-BroMo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09

1246765-38-7, 6-BroMo-3,4-dihydroquinazolin-2(1H)-oneRelated Search:


  • 6-BroMo-3,4-dihydroquinazolin-2(1H)-one
  • 6-Bromo-3,4-dihydro-1H-quinazolin-2-one
  • 6-Bromo-3,4-dihydroquinazolin-2(1H)
  • 6-Bromo-3,4-dihydro-1H-quizolin-2-one
  • 2(1H)-Quinazolinone, 6-bromo-3,4-dihydro-
  • 1246765-38-7