8-Nitroquinolin-2(1H)-one

Product Name: 8-Nitroquinolin-2(1H)-one
CAS No.: 7461-12-3
Chemical Name: 8-Nitroquinolin-2(1H)-one
Synonyms: 8-nitroquinolin-2-ol;8-Nitroquinolin-2(1H)-one;2(1H)-Quinolinone, 8-nitro-;8-nitro-1,2-dihydroquinolin-2-one
CBNumber: CB72661765
Molecular Formula: C9H6N2O3
Formula Weight: 190.16
MOL File: 7461-12-3.mol

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8-Nitroquinolin-2(1H)-one Property

storage temp.: Sealed in dry,Room Temperature

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N520153
Product name: 8-Nitroquinolin-2(1H)-one
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR925748
Product name: 8-Nitroquinolin-2(1H)-one
Purity: 95%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: OR925748
Product name: 8-Nitroquinolin-2(1H)-one
Purity: 95%
Packaging: 1g
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: Z5094
Product name: 8-Nitroquinolin-2(1H)-one
Packaging: 250mg
Price: $135
Updated: 2021/12/16

Apolloscientific

Product number: OR925748
Product name: 8-Nitroquinolin-2(1H)-one
Purity: 95%
Packaging: 5g
Price: $380
Updated: 2021/12/16

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8-Nitroquinolin-2(1H)-one Chemical Properties,Usage,Production

Synthesis

4225-86-9

7461-12-3

General procedure for the synthesis of 8-nitroquinolin-2(1H)-ones from 2-chloro-8-nitroquinoline: 2-chloro-8-nitroquinoline (1 equiv.) was dissolved in acetonitrile (25 mL) and 70% perchloric acid solution (25 mL) was added. The reaction mixture was stirred at 100°C overnight. Upon completion of the reaction, the mixture was poured into ice water and neutralized to neutral with KOH solution. The organic layer was extracted twice with dichloromethane and combined. The organic layer was washed with water and then dried with anhydrous MgSO4. After drying, the solvent was removed by vacuum evaporation to give the crude product. Purification by silica gel column chromatography using a suitable eluent and recrystallization if necessary gave the target compound 8-nitroquinolin-2(1H)-one. Isolation of 4-methyl-8-nitroquinolin-2(1H)-one 7 (C10H8N2O3) and recrystallization resulted in a yellow solid in acetonitrile in 92% yield (11 mmol, 2.2 g).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 135 - 152
[2] ChemMedChem, 2018,
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000, vol. 4, p. 555 - 562
[4] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 112
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 76

8-Nitroquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Nitroquinolin-2(1H)-one Suppliers

China 29 India 2 United Kingdom 1 United States 3 Global 35

Beijing Ouhe Technology Co., Ltd

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View Lastest Price from 8-Nitroquinolin-2(1H)-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 8-Nitroquinolin-2(1H)-one 7461-12-3
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-07

Career Henan Chemical Co

Product: 8-Nitroquinolin-2(1H)-one 7461-12-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

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8-nitro-1,2-dihydroquinolin-2-one

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7461-12-3