SC 144

ChemicalBook > CAS DataBase List > SC 144

Product Name: SC 144
CAS No.: 895158-95-9
Chemical Name: SC 144
Synonyms: SC144;SC 144;SC-144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
CBNumber: CB72666896
Molecular Formula: C16H11FN6O
Formula Weight: 322.3
MOL File: 895158-95-9.mol

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SC 144 Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
form: solid
pka: 8.87±0.43(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S199000
Product name: SC144
Packaging: 100mg
Price: $1680
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48649
Product name: SC144
Packaging: 100mg
Price: $2525
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb146229
Product name: SC144
Purity: >98%
Packaging: 1g
Price: $2691.1
Updated: 2021/12/16

AK Scientific

Product number: SYN5458
Product name: SC144 hydrochloride
Packaging: 10mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-4440
Product name: SC144
Purity: 98.60%
Packaging: 25mg
Price: $170
Updated: 2021/12/16

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SC 144 Chemical Properties,Usage,Production

Uses

SC144 is an orally active small-molecule gp130 inhibitor.

Biological Activity

sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a ﬁrst-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].

References

[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.

SC 144 Preparation Products And Raw materials

Raw materials

Preparation Products

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895158-95-9, SC 144Related Search:

Pyrrole Trifluoroacetic acid 2,5-PYRIDINEDICARBOXYLIC ACID Octyl 4-methoxycinnamate Polyoxytrifluoro(trifluoromethyl)-1,2-ethanediyl, .alpha.-(1-carboxy-1,2,2,2-tetrafluoroethyl)-.omega.-tetrafluoro(trifluoromethyl)ethoxy- Bortezomib 2-METHOXYESTRADIOL PD 0325901 Belinostat (PXD101) Luminespib Crizotinib

2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide

2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide

SC 144

SC144

SC-144

Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide

SC 144; SC144

CS-805

SC144;SC-144;SC 144

N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide

N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide

895158-95-9

C16H11FN6O

Inhibitors