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PLX647

Product Name
PLX647
CAS No.
873786-09-5
Chemical Name
PLX647
Synonyms
PLC647;PLX647;CS-1696;PLX 647;PLX-647;[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine;5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine;5-({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[4-(trifluoromethyl)phenyl]methyl}pyridin-2-amine;2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-
CBNumber
CB72667277
Molecular Formula
C21H17F3N4
Formula Weight
382.38
MOL File
873786-09-5.mol
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PLX647 Property

Density 
1.358±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
13.73±0.40(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18012
Product name
PLX647
Purity
≥95%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
18012
Product name
PLX647
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
18012
Product name
PLX647
Purity
≥95%
Packaging
25mg
Price
$433
Updated
2024/03/01
Cayman Chemical
Product number
18012
Product name
PLX647
Purity
≥95%
Packaging
50mg
Price
$768
Updated
2024/03/01
TRC
Product number
P635003
Product name
PLX647
Packaging
10mg
Price
$100
Updated
2021/12/16
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PLX647 Chemical Properties,Usage,Production

Description

PLX647 is a dual inhibitor of the receptor tyrosine kinases FMS and KIT (IC50s = 28 and 16 nM, respectively). It is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at a concentration of 1 μM. PLX647 inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells that express endogenous FMS and KIT, respectively (IC50s = 380 and 230 nM, respectively). It has no effect on HEK293T or HepG2 cells that lack FMS and KIT (IC50 = >50 μM) or Ba/F3 cells overexpressing KDR (IC50 = >5 μM). PLX647 also inhibits differentiation of human osteoclast precursor cells (IC50 = 170 nM). In vivo, PLX647 (40 mg/kg) reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release. It reduces mast cell degranulation in a mouse model of passive cutaneous anaphylaxis (PCA) and inhibits bone destruction and delays disease progression in a mouse model of collagen-induced arthritis (CIA). PLX647 also reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain.

Uses

PLX647 is a novel tyrosine kinase (TK) inhibitor, which selectively targets c-Kit and c-Fms.

References

[1]. zhang c, ibrahim pn, zhang j, et al. design and pharmacology of a highly specific dual fms and kit kinase inhibitor. proc natl acad sci u s a, 2013, 110(14): 5689-5694.

PLX647 Preparation Products And Raw materials

Raw materials

Preparation Products

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PLX647 Suppliers

China 48 China Hong Kong 1 United Kingdom 1 United States 13 Global 63
MedChemexpress LLC
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InvivoChem
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Cckinase, Inc.
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BOC Sciences
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ApexBio Technology
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Cayman Chemical Company
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United States Biological
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MedChemExpress
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Riedel-de Haen AG
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873786-09-5, PLX647Related Search:

PLX-4720 PLX7904

  • PLX647
  • PLC647
  • 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine
  • 2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-
  • PLX 647;PLX-647
  • CS-1696
  • [5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine
  • 5-({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[4-(trifluoromethyl)phenyl]methyl}pyridin-2-amine
  • 873786-09-5
  • C21H17F3N4
  • Inhibitors