BVT 2733
- Product Name
- BVT 2733
- CAS No.
- 376640-41-4
- Chemical Name
- BVT 2733
- Synonyms
- BVT2733, >98%;BVT 2733(BVT.2733);BVT.2733 >=98% (HPLC);3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide;BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
- CBNumber
- CB72667358
- Molecular Formula
- C17H21ClN4O3S2
- Formula Weight
- 428.96
- MOL File
- 376640-41-4.mol
BVT 2733 Property
- Boiling point:
- 636.9±65.0 °C(Predicted)
- Density
- 1.427±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 6.36±0.10(Predicted)
- color
- Off-white to pink
Safety
- HS Code
- 2935909099
N-Bromosuccinimide Price
- Product number
- SML1205
- Product name
- BVT.2733
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML1205
- Product name
- BVT.2733
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $370
- Updated
- 2024/03/01
- Product number
- 22203
- Product name
- BVT 2733
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 22203
- Product name
- BVT 2733
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 22203
- Product name
- BVT 2733
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $400
- Updated
- 2024/03/01
BVT 2733 Chemical Properties,Usage,Production
Uses
BVT 2733 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1.
Biological Activity
ki: 1 μm using 11-dehydrocorticosterone as substratebvt 2733 is a novel, small molecule, non-steroidal, and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-hsd1).11β-hsd1 has been reported to alter glucocorticoid hormone action in target tissues for insulin action and is suggested to play a key role in glucose homeostasis.
in vitro
bvt 2733 was identified as a novel type 1 selective inhibitor of murine 11β-hsd1 (ki 1 μmol/l), which did not inhibit mouse 11β-hsd type 2 at a concentration as high as 200 μmol/l (corresponding to a ki >33 μmol/l). therefore, the selectivity of bvt 2733 for the 11β-hsd type 1 enzyme over the type 2 enzyme was estimated to be at least 30-fold based on the ki values [1].
in vivo
in mice, bvt 2733 treatment could lower hepatic pepck and glucose-6-phosphatase mrna, serum insulin and blood glucose concentrations compared with vehicle treated mice. in contrast, hepatic 11beta-hydroxysteroid dehydrogenase type 1 mrna, liver function marker enzyme expression including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatases, body weight as well as daily food intake were not changed by the treatment of bvt 2733 [1].
References
[1] alberts p,engblom l,edling n,forsgren m,klingstrm g,larsson c,rnquist-nii y,ohman b,abrahmsén l. selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. diabetologia.2002 nov;45(11):1528-32.
BVT 2733 Preparation Products And Raw materials
Raw materials
Preparation Products
BVT 2733 Suppliers
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View Lastest Price from BVT 2733 manufacturers
- Product
- 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide 376640-41-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05