kobe-2602

Product Name: kobe-2602
CAS No.: 454453-49-7
Chemical Name: kobe-2602
Synonyms: CS-1280;Kos2602;kobe2602;kobe 2602;kobe-2602;kobe2602, >96%;Kobe 2602, >=98%;KOBE 2602; KOBE-2602;2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide;Hydrazinecarbothioamide, 2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)-
CBNumber: CB72667510
Molecular Formula: C14H9F4N5O4S
Formula Weight: 419.31
MOL File: 454453-49-7.mol

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kobe-2602 Property

Boiling point:: 450.8±55.0 °C(Predicted)
Density: 1.691±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17 mg/mL in DMSO; ≥17.53 mg/mL in EtOH with ultrasonic
form: solid
pka: 9.35±0.70(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16262
Product name: Kobe 2602
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16262
Product name: Kobe 2602
Purity: ≥98%
Packaging: 50mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16262
Product name: Kobe 2602
Purity: ≥98%
Packaging: 100mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 16262
Product name: Kobe 2602
Purity: ≥98%
Packaging: 500mg
Price: $533
Updated: 2024/03/01

TRC

Product number: D480435
Product name: 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide
Packaging: 1g
Price: $1320
Updated: 2021/12/16

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kobe-2602 Chemical Properties,Usage,Production

Uses

2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.

Uses

Kobe 2602 is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.

Biological Activity

kobe2602 is a small-molecule inhibitor of ras with ki value of 149 μm [1].kobe2602 is a compound screened out by a computer-assisted search of about 160,000 compounds. it dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. 20 μm of kobe2602 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. besides that, in nih 3t3 cells transfected with h-rasg12v, kobe2602 inhibited the colony formation with ic50 value of 1.4 μm. kobe2602 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe2602 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg [1].

References

[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187.

kobe-2602 Preparation Products And Raw materials

Raw materials

Preparation Products

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kobe-2602 Suppliers

Canada 1 CHINA 62 India 1 United States 12 Global 76

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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ApexBio Technology

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Country: United States
ProdList: 6251
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Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

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Country: United States
ProdList: 6398
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NE Scientific

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View Lastest Price from kobe-2602 manufacturers

Career Henan Chemical Co

Product: KOBE-2602 454453-49-7
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 96%
Supply Ability: 10kg
Release date: 2019-09-04

454453-49-7, kobe-2602Related Search:

kobe 2602

kobe2602

kobe-2602

2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide

kobe-2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide

Kobe 2602, >=98%

kobe2602, >96%

CS-1280

KOBE 2602; KOBE-2602

Hydrazinecarbothioamide, 2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)-

H-Ras,Inhibitor,antiproliferative,Kobe-2602,carcinoma,Kobe 2602,Kobe2602,inhibit,Ras,Raf

Kos2602

454453-49-7

C14H9F4N5O4S

Inhibitors

Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals