AZD1656
- Product Name
- AZD1656
- CAS No.
- 919783-22-5
- Chemical Name
- AZD1656
- Synonyms
- AZD1656;AZD 1656;AZD-1656;AZD-2691;AZ-12501796;AZD-1656, 10 mM in DMSO;3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-[(2S)-1-methoxypropan-2-yl]oxy-N-(5-methylpyrazin-2-yl)benzamide;(S)-3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-((1-methoxypropan-2-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide;Benzamide, 3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-;Hexokinase IV,Glucokinase,AZD-1656,AZD1656,G6pc,G6P,ChREBP-β,hypoglycemia,inhibit,Inhibitor,Hexokinase D,epinephrine,glucagon,antihyperglycemic
- CBNumber
- CB72668128
- Molecular Formula
- C24H26N6O5
- Formula Weight
- 478.5
- MOL File
- 919783-22-5.mol
AZD1656 Property
- Boiling point:
- 635.0±55.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- solubility
- DMSO: Soluble: =10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml - form
- Solid
- pka
- 10.84±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Axon3062
- Product name
- AZD1656
- Purity
- 99%
- Packaging
- 5mg
- Price
- $181.5
- Updated
- 2021/12/16
- Product number
- BA171838
- Product name
- AZD 1656
- Packaging
- 10mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- CS-0008226
- Product name
- AZD1656
- Packaging
- 5mg
- Price
- $370
- Updated
- 2021/12/16
- Product number
- KIN0008617
- Product name
- (S)-3-((5-(AZETIDINE-1-CARBONYL)PYRAZIN-2-YL)OXY)-5-((1-METHOXYPROPAN-2-YL)OXY)-N-(5-METHYLPYRAZIN-2-YL)BENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.48
- Updated
- 2021/12/16
- Product number
- CS-0008226
- Product name
- AZD1656
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
AZD1656 Chemical Properties,Usage,Production
Uses
AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research[1][2][3].
in vivo
AZD1656 (0-9 mg/kg; oral gavage; daily; for 8 weeks; C57BL/6 mice) treatment shows lowered blood glucose and glucose excursion and raised insulin. Liver mRNA levels for various ChREBP target genes including carbohydrate response element binding protein beta isoform (ChREBP-β), G6pc, Pklr, Acly, Acac and Gpd2 are increased by AZD1656[1].
| Animal Model: | C57BL/6 mice[1] |
| Dosage: | 0 mg/kg, 2 mg/kg, 4.5 mg/kg, 9 mg/kg |
| Administration: | Oral gavage; daily; for 8 weeks |
| Result: | Administered 2 hours before the oral glucose tolerance test, lowered blood glucose and glucose excursion and raised insulin. |
References
[1] Brian E Ford, et al. Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge. Diabetes Obes Metab. 2020 Jun 10. DOI:10.1111/dom.14111
[2] Medicinal Chemistry, et al. Design and Development of the Glucokinase Activator AZD1656. Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 1, 185-220.
[3] Terri Mitchard, et al. The novel use of a heterozygous knockout mouse for embryofetal development assessment of a glucokinase activator. Birth Defects Res B Dev Reprod Toxicol. 2014 Apr;101(2):152-61. DOI:10.1002/bdrb.21102
[4] M. WARING. Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656[J]. MedChemComm, 2012, 3 1: 1077-1081. DOI: 10.1039/c2md20077e
AZD1656 Preparation Products And Raw materials
Raw materials
Preparation Products
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