GSK1265744 (sodiuM salt)
- Product Name
- GSK1265744 (sodiuM salt)
- CAS No.
- 1051375-13-3
- Chemical Name
- GSK1265744 (sodiuM salt)
- Synonyms
- Sodium Cabotegravir;Cabotegravir Sodium;GSK1265744 (sodiuM salt);GSK1265744 (GSK744) Sodium salt;GSK1265744 (sodiuM salt) ISO 9001：2015 REACH;Sodium (3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate;(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE, SODIUM SALT
- CBNumber
- CB72668193
- Molecular Formula
- C19H18F2N3NaO5
- Formula Weight
- 429.36
- MOL File
- 1051375-13-3.mol
GSK1265744 (sodiuM salt) Property
- storage temp.
- 4°C, away from moisture
- solubility
- DMSO : 6.9 mg/mL (16.15 mM; ultrasonic and warming and heat to 60°C)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- orb611943
- Product name
- Cabotegravir Sodium
- Purity
- >98%
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- orb611943
- Product name
- Cabotegravir Sodium
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1356.6
- Updated
- 2021/12/16
- Product number
- orb611943
- Product name
- Cabotegravir Sodium
- Purity
- >98%
- Packaging
- 1g
- Price
- $2691.1
- Updated
- 2021/12/16
- Product number
- CD11359572
- Product name
- Sodium(3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CD11359572
- Product name
- Sodium(3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $349
- Updated
- 2021/12/16
GSK1265744 (sodiuM salt) Chemical Properties,Usage,Production
Uses
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS[1][2].
Definition
ChEBI: Cabotegravir sodium is an organic sodium salt that is the monosodium salt of cabotegravir. Used for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It contains a cabotegravir(1-).
in vivo
The half-life of Cabotegravir is up to 54 days in mice[1].
Cabotegravir (25 or 50 mg/kg; i.v.; single dose or twice) protects Macaques against intravenous challenge with SIVmac251[4].
References
[1] Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65. DOI:10.1016/j.biomaterials.2017.10.023
[2] Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2016;46(5):445-56. DOI:10.3109/00498254.2015.1081993
[3] Yoshinaga T, et al. Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection. Antimicrob Agents Chemother. 2015 Jan;59(1):397-406. DOI:10.1128/AAC.03909-14
[4] Andrews CD, et al. Cabotegravir long acting injection protects macaques against intravenous challenge with SIVmac251. AIDS. 2017 Feb 20;31(4):461-467. DOI:10.1097/QAD.0000000000001343
GSK1265744 (sodiuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
GSK1265744 (sodiuM salt) Suppliers
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View Lastest Price from GSK1265744 (sodiuM salt) manufacturers
- Product
- CABOTEGRAVIR SODIUM; GSK1265744 (sodiuM salt) 1051375-13-3
- Price
- US $100.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 99% Purity (What/sapp: +86 18145728414)
- Supply Ability
- 1000 Tons/Month
- Release date
- 2023-06-30
- Product
- GSK1265744 (sodiuM salt) 1051375-13-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-11