tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate

Uses

Product Name: tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate
CAS No.: 917342-29-1
Chemical Name: tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate
Synonyms: trans-4-(Boc-amino)cyclohexaneethanol;tert-butyl N-[4-(2-hydroxyethyl)cyclohexyl]carbamate;ert-Butyltrans-4-(2-hydroxyethyl)-cyclohexylcarbamate;trans-1-(Boc-aMino)-4-(2-hydroxyethyl)cyclohexane, 97%;trans-2-[4-[(tert-Butoxycarbonyl)amino]cyclohexyl]ethanol;trans 2-{1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl}et...;trans 2-{1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl}ethanol;N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl esterCarbaMic acid;CarbaMic acid, N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl ester
CBNumber: CB72668724
Molecular Formula: C13H25NO3
Formula Weight: 243.34
MOL File: 917342-29-1.mol

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tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate Property

Boiling point:: 366.0±11.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.56±0.40(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C13H25NO3/c1-13(2,3)17-12(16)14-11-6-4-10(5-7-11)8-9-15/h10-11,15H,4-9H2,1-3H3,(H,14,16)/t10-,11-
InChIKey: KTNFSGIXLVLQNK-XYPYZODXSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](CCO)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 3162AF
Product name: tert-Butyltrans-4-(2-hydroxyethyl)-cyclohexylcarbamate
Packaging: 1g
Price: $667
Updated: 2021/12/16

Matrix Scientific

Product number: 089383
Product name: tert-Butyl trans-4-(2-hydroxyethyl)-cyclohexylcarbamate
Packaging: 200mg
Price: $710
Updated: 2021/12/16

Matrix Scientific

Product number: 089383
Product name: tert-Butyl trans-4-(2-hydroxyethyl)-cyclohexylcarbamate
Packaging: 1g
Price: $1498
Updated: 2021/12/16

Matrix Scientific

Product number: 089383
Product name: tert-Butyl trans-4-(2-hydroxyethyl)-cyclohexylcarbamate
Packaging: 5g
Price: $4568
Updated: 2021/12/16

Crysdot

Product number: CD13001339
Product name: tert-Butyl(trans-4-(2-hydroxyethyl)cyclohexyl)carbamate
Purity: 95+%
Packaging: 250mg
Price: $238
Updated: 2021/12/16

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tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate Chemical Properties,Usage,Production

Uses

Tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate can be used for preparing quinolinones and analogs for treating multi-drug resistant bacterial infections. It can also be used for preparing the antipsychotic drug Cariprazine.

Uses

trans-1-(Boc-amino)-4-(2-hydroxyethyl)cyclohexane can be used for preparing quinolinones and analogs for treating multi-drug resistant bacterial infections. It can also be used for preparing the antipsychotic drug Cariprazine.

Application

(trans-4-Hydroxymethylcyclohexyl)carbamic Acid tert-Butyl Ester is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors. It is also used to prepare Mer kinase inhibitors for treatment of pediatric acute lymphoblastic leukemia.

Synthesis

An 500 ml four-necked flask is charged with 40 g (0,18 mol) of trans 2-[1-(4-amino]- cyclohexyl)-acetic acid ethyl ester hydrochloride and 160 ml of dichloromethane. To the resulting suspension 18,2 g (0,18 mol) of triethylamine is added. The reaction mixture is cooled to a temperature between 8-10°C and a solution of 40,0 g (0,185 mol) of di(tert-butyl)dicarbonate in 100 ml of dichloromethane is added for 1 hour with stirring under nitrogen. Then the reaction mixture is allowed to warm to a temperature between 22-25°C and stirred until the reaction proceeds. After completion of the reaction 100 g of 5% aqueous sodium carbonate is added and the phases are separated. The organic layer is extracted with 50 ml of water and after separation the organic layer is dried under Na2SO4 and the filtrate is concentrated in vacuum. The trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-acetic acid ethyl ester obtained is dissolved in 460 ml of tetrahydrofurane then 13,68 g (0,36 mol) of sodium borohydride is added at 25°C under nitrogen. With stirring, to the reaction mixture a solution of 24,0 g (0,18 mol) of aluminium chloride in 250 ml abs. tetrahydrofurane is added dropwise at a temperature between 18-22°C for 1 hour under nitrogen then the mixture is stirred for additional 2 hours. After completion of the reaction the mixture is cooled to a temperature between 5-10°C and 650 ml of water and 600 ml of toluene are added. Then the pH was adjusted to 3-4 by adding 40-45 ml of concentrated hydrochloric acid and the stirring was continued at a temperature between 20-25°C for 1 hour. The phases are separated, the aqueous layer is extracted with 50 ml of toluene and the combined organic layers are washed with 3×150 ml of water and dried in vacuum. In this manner 41,1 g of title compound was obtained. Yield: 94% 20. Melting point: 101-103°C.

References

[1] Patent: CN106543039, 2017, A. Location in patent: Paragraph 0076-0079

tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate Preparation Products And Raw materials

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Preparation Products

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tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate Suppliers

Canada 1 China 89 France 2 Germany 2 India 7 United States 14 Global 115

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View Lastest Price from tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: trans-1-(Boc-amino)-4-(2-hydroxyethyl)cyclohexane 917342-29-1
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-29

Shanghai Yongzeng Technology Co.,Ltd

Product: tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate 917342-29-1
Price: US $0.00/kg
Min. Order: 0.1kg
Purity: 99%
Supply Ability: 100kgs
Release date: 2024-09-03

Shaanxi Dideu New Materials Co. Ltd

Product: CarbaMic acid, N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl ester 917342-29-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

917342-29-1, tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamateRelated Search:

Desmethyl Cariprazine Piperazine, 1-(2-chloroethyl)-4-(2,3-dichlorophenyl)- Urea, N,N'-bis[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]- Urea, N,N-dimethyl-N'-[trans-4-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]cyclohexyl]- ethyl dimethylcarbamate 3,3-dimethyl-1-[(1r,4r)-4-(2-hydroxyethyl)cyclohexyl]urea Cyclohexaneethanol, 4-amino-, hydrochloride (1:1), trans- trans-4-Aminocyclohexanol Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Ethyl trans-2-[4-(Boc-aMino)cyclohexyl]acetate

trans-4-(Boc-amino)cyclohexaneethanol

CarbaMic acid, N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl ester

trans-1-(Boc-aMino)-4-(2-hydroxyethyl)cyclohexane, 97%

N-[trans-4-(2-hydroxyethyl)cyclohexyl]-, 1,1-diMethylethyl esterCarbaMic acid

trans-2-[4-[(tert-Butoxycarbonyl)amino]cyclohexyl]ethanol

trans 2-{1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl}ethanol

trans 2-{1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl}et...

ert-Butyltrans-4-(2-hydroxyethyl)-cyclohexylcarbamate

tert-butyl N-[4-(2-hydroxyethyl)cyclohexyl]carbamate

917342-29-1