GSK 2830371

Product Name: GSK 2830371
CAS No.: 1404456-53-6
Chemical Name: GSK 2830371
Synonyms: GSK 2830371;GSK 2830371 USP/EP/BP;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
CBNumber: CB72682001
Molecular Formula: C23H29ClN4O2S
Formula Weight: 461.02
MOL File: 1404456-53-6.mol

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GSK 2830371 Property

Boiling point:: 704.1±60.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 13.29±0.46(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1048
Product name: GSK2830371
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1048
Product name: GSK2830371
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 16973
Product name: GSK2830371
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16973
Product name: GSK2830371
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 16973
Product name: GSK2830371
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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GSK 2830371 Chemical Properties,Usage,Production

Uses

GSK 2830371 is used in biological studies as allosteric Wip1(wild-type p54-induced phosphatase) inhibition through flap-subdomain interaction.

Biochem/physiol Actions

GSK2830371 is an orally active allosteric inhibitor of wild-type p53-induced phosphatase (Wip1, also known as PPM1D/ PP2Cδ), an oncogenic type 2C serine/threonine phosphatase that negatively regulates key proteins in the DNA damage–response pathway. GSK2830371 is selective for Wip1 with an IC50 of 6 nM against Wip1 compared to >10 μM IC50 for PPM1A & PPM1K, and >30 μM IC50 for 22 other phosphatases tested. GSK2830371 is believed to interact with the flap subdomain located near the Wip1 catalytic site, a feature that distinguishes Wip1 from other members of the protein phosphatase 2C (PP2C) family. GSK2830371 increased phosphorylation of Wip1 substrates and caused growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

storage

Store at -20°C

GSK 2830371 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 2830371 Suppliers

China 92 United Kingdom 2 United States 15 Global 109

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

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Sigma-Aldrich

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SPIRO PHARMA

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1404456-53-6, GSK 2830371Related Search:

Panobinostat GDC-0068 L-NORADRENALINE BITARTRATE (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone Erlotinib hydrochloride Canertinib

5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide

GSK 2830371

5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide

(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide

2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-

GSK 2830371 USP/EP/BP

GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide

1404456-53-6

C23H29ClN4O2S

Inhibitors