ChemicalBook > CAS DataBase List > 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-

1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-

Product Name: 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
CAS No.: 866862-25-1
Chemical Name: 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
Synonyms: 5-Bromo-6-fluoro-1-indanone;1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
CBNumber: CB72684878
Molecular Formula: C9H6BrFO
Formula Weight: 229.05
MOL File: 866862-25-1.mol

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1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Property

Boiling point:: 301.4±42.0 °C(Predicted)
Density: 1.691±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to yellow Solid

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Safety

HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC908171
Product name: 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
Purity: 95%
Packaging: 250mg
Price: $345
Updated: 2021/12/16

Apolloscientific

Product number: PC908171
Product name: 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
Purity: 95%
Packaging: 1g
Price: $765
Updated: 2021/12/16

AK Scientific

Product number: 9563DT
Product name: 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
Packaging: 1g
Price: $1302
Updated: 2021/12/16

JR MediChem

Product number: JR6-L1725
Product name: 1H-Inden-1-one,5-bromo-6-fluoro-2,3-dihydro-
Purity: 96%
Packaging: 5g
Price: $780
Updated: 2021/12/16

Ambeed

Product number: A104440
Product name: 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
Purity: 95+%
Packaging: 100mg
Price: $133
Updated: 2021/12/16

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1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Chemical Properties,Usage,Production

Synthesis

866862-24-0

866862-25-1

The general procedure for the synthesis of 5-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one using 3-(3-bromo-4-fluorophenyl)propionic acid as starting material was as follows: 3-(3-bromo-4-fluorophenyl)propionic acid (3.5 g, 14.2 mmol) was dissolved in a solvent mixture of dichloromethane (25 mL) and N,N-dimethylformamide (0.5 mL) at room temperature. Oxalyl chloride (7.2 g, 56.7 mmol) was then added. The reaction mixture was continued to be stirred for 30 min before the solvent was removed by distillation under reduced pressure. The resulting residue was redissolved in dichloromethane (50 mL) and added slowly and dropwise to a refluxing suspension of pre-prepared aluminum trichloride (7.6 g, 56.7 mmol) in dichloromethane (200 mL). The reaction mixture was kept under reflux conditions for 90 min, followed by pouring into an ice/concentrated hydrochloric acid mixture to quench the reaction. Extraction was carried out with dichloromethane (3 x 200 mL) and concentrated under reduced pressure after combining the organic phases. Finally, the residue was purified by column chromatography (eluent 25% petroleum ether solution of ethyl acetate) to afford the target compound 5-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one as a light yellow solid (2.1 g, 68% yield). Mass spectrometry analysis (ESI) showed that the calculated value of [M+H]+ was 229 (C9H6BrFO) and the measured value was 229.

References

[1] Patent: WO2014/74422, 2014, A1. Location in patent: Paragraph 00181

1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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866862-25-1, 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-Related Search:

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5-Bromo-6-fluoro-1-indanone

866862-25-1