Methyl azepane-4-carboxylate hydrochloride

Product Name: Methyl azepane-4-carboxylate hydrochloride
CAS No.: 1383132-15-7
Chemical Name: Methyl azepane-4-carboxylate hydrochloride
Synonyms: methyl azepane-4-carboxylate HCl;Methyl hexahydro-1H-azepine-4-carboxylate hydrochloride;1H-Azepine-4-carboxylic acid, hexahydro-, methyl ester, hydrochloride (1:1)
CBNumber: CB72685512
Molecular Formula: C8H16ClNO2
Formula Weight: 193.67114
MOL File: 1383132-15-7.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M287768
Product name: methylazepane-4-carboxylatehydrochloride
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 124450
Product name: Methylhexahydro-1H-azepine-4-carboxylatehydrochloride
Purity: 95+%
Packaging: 1g
Price: $1254
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052457
Product name: METHYL AZEPANE-4-CARBOXYLATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $456.61
Updated: 2021/12/16

AK Scientific

Product number: Y6046
Product name: Methylazepane-4-carboxylatehydrochloride
Packaging: 5g
Price: $2262
Updated: 2021/12/16

AK Scientific

Product number: Y6046
Product name: Methylazepane-4-carboxylatehydrochloride
Packaging: 10g
Price: $4159
Updated: 2021/12/16

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Methyl azepane-4-carboxylate hydrochloride Chemical Properties,Usage,Production

Uses

Methyl azepane-4-carboxylate hydrochloride can be used to prepare methyl 1-(2-chloro-5-(3-methoxypropyl)pyridin-3-yl)azepane-4-carboxylate by reacting with 3-bromo-2-chloro-5-(3-methoxypropyl)pyridine. The specific synthesis steps are as follows:
To a stirred solution of 3-bromo-2-chloro-5-(3-methoxypropyl)pyridine (200 mg, 756 μmol, 1 .0 eq) in toluene (2 mL), was added methyl azepane-4-carboxylate HCl (190 mg, 983 μmol, 1.3 eq), and Cs2CO3(739 mg, 2.27 mmol, 3 eq). The resulting reaction mixture was purged with N2 (g) for 10 min. Next, Pd2(dba)3 (35 mg, 38 μmol, 0.05 eq) and 9,9-dimethyl-9H-xanthene-4,5- diyl)bis(diphenylphosphane) (Xantphos) (44 mg, 76 μmol, 0.1 eq) were added respectively and the resulting reaction mixture was again purged with N2 (g) for 5 min. The resulting reaction mixture was heated to 110°C and stirred for 16 hr. The reaction mixture was then cooled to rt and filtered. The filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (PE:EtOAc=10: 1 to 5:1) to afford methyl 1 -(2- chloro-5 -(3 -methoxy propyl)pyridin-3-yl)azepane-4-carboxylate (80 mg, 31 % yield) as colorless liquid. LCMS calculated for C17H25CIN2O3: m/z = 340; found: m/z = 341 (M+H).

Methyl azepane-4-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1383132-15-7, Methyl azepane-4-carboxylate hydrochlorideRelated Search:

Methyl hexahydro-1H-azepine-4-carboxylate hydrochloride

methyl azepane-4-carboxylate HCl

1H-Azepine-4-carboxylic acid, hexahydro-, methyl ester, hydrochloride (1:1)

1383132-15-7