Methyl azepane-4-carboxylate hydrochloride
- Product Name
- Methyl azepane-4-carboxylate hydrochloride
- CAS No.
- 1383132-15-7
- Chemical Name
- Methyl azepane-4-carboxylate hydrochloride
- Synonyms
- methyl azepane-4-carboxylate HCl;Methyl hexahydro-1H-azepine-4-carboxylate hydrochloride;1H-Azepine-4-carboxylic acid, hexahydro-, methyl ester, hydrochloride (1:1)
- CBNumber
- CB72685512
- Molecular Formula
- C8H16ClNO2
- Formula Weight
- 193.67114
- MOL File
- 1383132-15-7.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M287768
- Product name
- methylazepane-4-carboxylatehydrochloride
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 124450
- Product name
- Methylhexahydro-1H-azepine-4-carboxylatehydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1254
- Updated
- 2021/12/16
- Product number
- CHM1052457
- Product name
- METHYL AZEPANE-4-CARBOXYLATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $456.61
- Updated
- 2021/12/16
- Product number
- Y6046
- Product name
- Methylazepane-4-carboxylatehydrochloride
- Packaging
- 5g
- Price
- $2262
- Updated
- 2021/12/16
- Product number
- Y6046
- Product name
- Methylazepane-4-carboxylatehydrochloride
- Packaging
- 10g
- Price
- $4159
- Updated
- 2021/12/16
Methyl azepane-4-carboxylate hydrochloride Chemical Properties,Usage,Production
Uses
Methyl azepane-4-carboxylate hydrochloride can be used to prepare methyl 1-(2-chloro-5-(3-methoxypropyl)pyridin-3-yl)azepane-4-carboxylate by reacting with 3-bromo-2-chloro-5-(3-methoxypropyl)pyridine. The specific synthesis steps are as follows:
To a stirred solution of 3-bromo-2-chloro-5-(3-methoxypropyl)pyridine (200 mg, 756 μmol, 1 .0 eq) in toluene (2 mL), was added methyl azepane-4-carboxylate HCl (190 mg, 983 μmol, 1.3 eq), and Cs2CO3(739 mg, 2.27 mmol, 3 eq). The resulting reaction mixture was purged with N2 (g) for 10 min. Next, Pd2(dba)3 (35 mg, 38 μmol, 0.05 eq) and 9,9-dimethyl-9H-xanthene-4,5- diyl)bis(diphenylphosphane) (Xantphos) (44 mg, 76 μmol, 0.1 eq) were added respectively and the resulting reaction mixture was again purged with N2 (g) for 5 min. The resulting reaction mixture was heated to 110°C and stirred for 16 hr. The reaction mixture was then cooled to rt and filtered. The filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (PE:EtOAc=10: 1 to 5:1) to afford methyl 1 -(2- chloro-5 -(3 -methoxy propyl)pyridin-3-yl)azepane-4-carboxylate (80 mg, 31 % yield) as colorless liquid. LCMS calculated for C17H25CIN2O3: m/z = 340; found: m/z = 341 (M+H).
Methyl azepane-4-carboxylate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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