ApiliMod (Mesylate)

Product Name: ApiliMod (Mesylate)
CAS No.: 870087-36-8
Chemical Name: ApiliMod (Mesylate)
Synonyms: LAM-002A;Apilimodmesilate;STA5326 mesylate;AIT-101 mesylate;STA-5326 mesylate;STA 5326 mesylate;Apilimod dimesylate;ApiliMod (Mesylate);Apilimodmesylate, >98%;Dimethanesulfonic acid
CBNumber: CB72685921
Molecular Formula: C24H30N6O5S
Formula Weight: 514.6
MOL File: 870087-36-8.mol

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ApiliMod (Mesylate) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 7283
Product name: Apilimoddimesylate
Purity: ≥98%(HPLC)
Packaging: 5
Price: $139
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA177431
Product name: Apilimod mesylate NEW
Packaging: 25mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA177431
Product name: Apilimod mesylate NEW
Packaging: 50mg
Price: $375
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA177431
Product name: Apilimod mesylate NEW
Packaging: 100mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-2342
Product name: Apilimod(mesylate)
Purity: 99.40%
Packaging: 100mg
Price: $520
Updated: 2021/12/16

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ApiliMod (Mesylate) Chemical Properties,Usage,Production

Uses

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively[1]. Apilimod is a potent and highly selective PIKfyve inhibitor.

in vivo

Apilimod (10 mg/kg, p.o.) is effective not only when administered throughout the entire experiment, but also when administration is initiated on day 30 when disease is clearly measurable but not maximal. Apilimod causes a significant reduction in cell number only in the Th1 model, with an average percentage of inhibition of 51%±8% relative to the vehicle control. Apilimod treatment has no effect in the Th2 setting^[1]. Apilimod (5 or 20 mg/kg, p.o.) reduces the level of IL-12 p40 in serum without altering body weight in EAU mice. Oral administration of Apilimod reduces the severity of experimental autoimmune uveoretinitis (EAU) by clinical and histopathological analysis^[2].

IC 50

IL-4; IL-5; IL-8; IL-12; IL-23

storage

Store at -20°C

References

[1] Wada Y, et al. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007 Feb 1;109(3):1156-64. DOI:10.1182/blood-2006-04-019398
[2] Billich A. Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency.IDrugs. 2007 Jan;10(1):53-9. PMID:17187316
[3] Keino H, et al. Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther. 2008;10(5):R122. DOI:10.1186/ar2530

ApiliMod (Mesylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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ApiliMod (Mesylate) Suppliers

China 85 India 1 United States 6 Global 92

Shanghai JiYi Biotechnology Co. Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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D&C Chemicals

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SPIRO PHARMA

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ShangHai Siyan Biological Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai QianYan Bio-technology Co., Ltd

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Shanghai Changyan Chem & Tech Co., Ltd.

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View Lastest Price from ApiliMod (Mesylate) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Apilimod mesylate 870087-36-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Apilimod mesylate 870087-36-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: ApiliMod (Mesylate) 870087-36-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

870087-36-8, ApiliMod (Mesylate)Related Search:

STA 5326 mesylate

STA 5326 MESYLATE; STA5326 MESYLATE; STA-5326 MESYLATE

STA5326 mesylate

STA-5326 mesylate

Apilimodmesylate, >98%

ApiliMod (Mesylate)

(E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine methanesulfonate

Apilimod dimesylate

Apilimodmesilate

(E)-4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

Apilimod,inhibit,Interleukin Related,STA-5326,Fab1,STA5326,STA 5326,Apilimod mesylate,Inhibitor,PIKfyve

Apilimod (STA-5326) mesylate

Benzaldehyde, 3-methyl-,[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone,dimethanesulfonate

Apilimod mesylate, 10 mM in DMSO

AIT-101 mesylate

LAM-002A

Dimethanesulfonic acid

(e)-4-(6-(2-(3-methylbenzylidene)hydrazineyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

870087-36-8

C23H26N6O22CH4O3S

C25H34N6O8S2