Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate

Product Name: Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate
CAS No.: 118159-48-1
Chemical Name: Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate
Synonyms: SY801;CS-1347;Bicyclol;Bicyclol, SY 801;Bicyclol USP/EP/BP;Bifendate Impurity 17;Bifendate Impurity 6 (Bicyclol);Bicyclol,SY 801,SY-801,Inhibitor,Hepatitis B virus,Autophagy,inhibit,HBV;Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate;Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate
CBNumber: CB72693359
Molecular Formula: C19H18O9
Formula Weight: 390.34
MOL File: 118159-48-1.mol

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Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate Property

Boiling point:: 608.1±55.0 °C(Predicted)
Density: 1.410±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: >10mg/mL
pka: 13.85±0.10(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
RTECS: DT4312000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21551
Product name: Bicyclol
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21551
Product name: Bicyclol
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21551
Product name: Bicyclol
Purity: ≥98%
Packaging: 10mg
Price: $142
Updated: 2024/03/01

TRC

Product number: B382913
Product name: Bicyclol
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-2968
Product name: Bicyclol
Purity: 99.97%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate Chemical Properties,Usage,Production

Description

Bicyclol is a hepatoprotective agent. It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells. In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses ≥0.4 g/kg. It also reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A . Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital (PB; Item Nos. 9001494 | 20987) prevents formation of DEN/PB-induced hepatocellular carcinomas. It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.

Uses

Bicyclol is a novel hepatoprotectant shown to protect against liver injury by inducing Hsps, including Hsp27 and Hsp 70; Anti-inflammatory activity.

Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate Suppliers

China 58 India 1 United States 11 Global 70

Shanghai Rechem science Co., Ltd.

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Allikang Pharmaceutical Co., LTD

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MedChemexpress LLC

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Shanghai YuanYe Biotechnology Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

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View Lastest Price from Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate manufacturers

Dideu Industries Group Limited

Product: Bicyclol
Price: US $1.10/g
Min. Order: 1g
Purity: 0.999
Supply Ability: 100 Tons min
Release date: 2021-07-30

Career Henan Chemical Co

Product: Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate 118159-48-1
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 100kg； 500kg
Release date: 2019-12-24

118159-48-1, Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylateRelated Search:

4-(HYDROXYMETHYL)BENZONITRILE 1,1,1-Tris(hydroxymethyl)ethane

Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate

Bicyclol

4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl

Bicyclol, SY 801

CS-1347

methyl 4-[5-(hydroxymethyl)-7-methoxy-1,3-benzodioxol-4-yl]-7-methoxy-1,3-benzodioxole-5-carboxylate

SY801

[4,4'-Bi-1,3-benzodioxole]-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester

Bicyclol USP/EP/BP

Bicyclol,SY 801,SY-801,Inhibitor,Hepatitis B virus,Autophagy,inhibit,HBV

Bifendate Impurity 17

Bifendate Impurity 6 (Bicyclol)

Methyl 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5-carboxylate

118159-48-1

C19H18O9