4-(HYDROXYMETHYL)BENZONITRILE

Product Name: 4-(HYDROXYMETHYL)BENZONITRILE
CAS No.: 874-89-5
Chemical Name: 4-(HYDROXYMETHYL)BENZONITRILE
Synonyms: 4-CYANOBENZYL ALCOHOL;4-cyanobeznyl alcohol;4-methylolbenzonitrile;4-Cyanobenzenemethanol;Tranexamic Acid Impurity 13;4-(HYDROXYMETHYL)BENZONITRILE;Benzonitrile,4-(hydroxyMethyl)-;4-(Hydroxymethyl)benzonitrile 95%;4-(hydroxymethyl)benzenecarbonitrile;4-((N-nitrosoacetamido)methyl)benzoic acid
CBNumber: CB9184327
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 874-89-5.mol

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4-(HYDROXYMETHYL)BENZONITRILE Property

Melting point:: 39-43 °C(lit.)
Boiling point:: 203 °C(Press: 53 Torr)
Density: 1.16±0.1 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
pka: 13.99±0.10(Predicted)
Appearance: White to light yellow Solid
Water Solubility: Insoluble in water.
BRN: 2206193
InChI: 1S/C8H7NO/c9-5-7-1-3-8(6-10)4-2-7/h1-4,10H,6H2
InChIKey: XAASLEJRGFPHEV-UHFFFAOYSA-N
SMILES: OCc1ccc(cc1)C#N

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
RIDADR: 3439
WGK Germany: 3
F: 10
HazardClass: 6.1
HS Code: 29269090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 527750
Product name: 4-(Hydroxymethyl)benzonitrile
Purity: 95%
Packaging: 10g
Price: $452
Updated: 2026/03/19

TRC

Product number: H972610
Product name: 4-(Hydroxymethyl)benzonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H972610
Product name: 4-(Hydroxymethyl)benzonitrile
Packaging: 1g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W003983
Product name: 4-Cyanobenzylalcohol
Purity: 99.45%
Packaging: 5g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC70532
Product name: 4-Cyanobenzyl alcohol
Packaging: 5G
Price: $55
Updated: 2021/12/16

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4-(HYDROXYMETHYL)BENZONITRILE Chemical Properties,Usage,Production

Uses

4-(Hydroxymethyl)benzonitrile [p-(hydroxymethyl)benzonitrile] may be used to synthesize p-((vinyloxy)methyl)benzonitrile (VOMBN).

Definition

ChEBI: 4-cyanobenzyl alcohol is an aromatic primary alcohol. It is functionally related to a benzyl alcohol.

General Description

4-(Hydroxymethyl)benzonitrile can be synthesized via hydrosilylation reaction in the presence of Fe complex Bu₄N[Fe(CO)₃(NO)] [catalyst]. It can also be prepared from 4-(aminomethyl) benzyl alcohol.

Synthesis

619-65-8

874-89-5

8A. Synthesis of 4-hydroxymethylbenzonitrile: Boron trifluoride diethyl ether compound (0.85 mL, 6.8 mmol) was slowly added to a solution containing 4-cyanobenzoic acid (1.0 g, 6.8 mmol) and tetrahydrofuran (10 mL). Borane-tetrahydrofuran complex (1.0 M, 13.6 mL) was added dropwise to the reaction mixture at room temperature, during which no significant exothermic phenomenon was observed. The reaction mixture was stirred continuously for 2 h at room temperature and then concentrated under vacuum. The obtained residue was dissolved in ethyl acetate (50 mL), washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated in vacuum to afford the target product 4-hydroxymethylbenzonitrile (0.900 g, 95% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 4.65 (s, 2H), 7.38 (d 2H), 7.53 (d, 2H).

References

[1] Patent: US2007/270438, 2007, A1. Location in patent: Page/Page column 39
[2] Tetrahedron Letters, 2003, vol. 44, # 16, p. 3427 - 3428
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 2-3, p. 308 - 312
[4] Dalton Transactions, 2016, vol. 45, # 19, p. 8265 - 8271

4-(HYDROXYMETHYL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(HYDROXYMETHYL)BENZONITRILE Suppliers

Belgium 1 Canada 1 China 130 Germany 5 India 8 Switzerland 1 Ukraine 2 United Kingdom 7 United States 31 Global 186

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View Lastest Price from 4-(HYDROXYMETHYL)BENZONITRILE manufacturers

Shanghai Rlavie Technology Co ltd

Product: 4-Cyanobenzyl alcohol 874-89-5
Price: US $0.00-0.00/kg
Min. Order: 0.0001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-09

Career Henan Chemical Co

Product: 4-(HYDROXYMETHYL)BENZONITRILE 874-89-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

874-89-5, 4-(HYDROXYMETHYL)BENZONITRILERelated Search:

4-(HYDROXYMETHYL)BENZONITRILE Methyl 4-cyanobenzoate Citalopram 5-Cyanophthalide TRANS-4-(5-PENTYL-1,3-DIOXAN-2-YL)BENZONITRILE 2-(4-CYANOPHENYL)-5-N-PROPYL-1,3-DIOXANE 4-Cyanobenzoic acid Ethyl 4-cyanobenzoate 4-[4-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-1-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITRILE, MONOHYDROBROMIDE (-)-4-(4-Dimethylamino)-1-(4-fluorophenyl)-1-(hydroxybuty)-3-hydroxymethyl)-benzonitrile hemi D-(+)-di-p-toloyltartaric acid salt 4-[1-(4-CYANOPHENYL)-HYDROXYMETHYL]-BENZONITRILE 3-(HYDROXYMETHYL)BENZONITRILE 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrochloride 3-Fluoro-4-(hydroxymethyl)benzonitrile 4-[(1S)-(4-dimethylamino)-1-(4-fluotophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 1/2(+)-Di-1,4-toluoyl-D-tartaric acid 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile Bis(4-cyanophenyl)methanol 4-oxiran-2-ylbenzonitrile

4-(HYDROXYMETHYL)BENZONITRILE

4-CYANOBENZYL ALCOHOL

4-Cyanobenzenemethanol

Tranexamic Acid Impurity 13

4-(hydroxymethyl)benzenecarbonitrile

4-methylolbenzonitrile

4-(Hydroxymethyl)benzonitrile 95%

4-cyanobeznyl alcohol

Benzonitrile,4-(hydroxyMethyl)-

4-(HydroxyMethyl)benzonitrile, puruM, >=97.0% (GC)

4-((N-nitrosoacetamido)methyl)benzoic acid

874-89-5

HOCH2C6H4CN

Organic Building Blocks

Nitrogen Compounds

Cyanides/Nitriles

Building Blocks

C8 to C9

Building Blocks

C8 to C9

Chemical Synthesis

Cyanides/Nitriles

Nitrogen Compounds

Organic Building Blocks

Benzhydrols, Benzyl & Special Alcohols