4-Cyano-2-fluorobenzyl alcohol

Product Name: 4-Cyano-2-fluorobenzyl alcohol
CAS No.: 219873-06-0
Chemical Name: 4-Cyano-2-fluorobenzyl alcohol
Synonyms: 3-Fluoro-4-(hydroxymethyl)benzonitrile;4-Cyano-2-florobenzyl alcohol;4-Cyano-2-fluorobenzyl alcohol;2-fluoro-4-cyanobenzyl alcohol;4-hydroxymethyl-3-fluorobenzonitrile;Benzonitrile, 3-fluoro-4-(hydroxymethyl)-;3-Fluoro-4-(hydroxymethyl)benzonitrile 97%;3-Fluoro-4-(hydroxymethyl)benzonitrile99+%;Benzonitrile, 3-fluoro-4-(hydroxymethyl)- (9CI);3-Fluoro-4-(Hydroxymethyl) Benzonitrile [FHMBN]
CBNumber: CB81058491
Molecular Formula: C8H6FNO
Formula Weight: 151.14
MOL File: 219873-06-0.mol

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4-Cyano-2-fluorobenzyl alcohol Property

Melting point:: 63-68°C
Boiling point:: 288.8±30.0 °C(Predicted)
Density: 1.27 g/mL at 25 °C
storage temp.: Sealed in dry,Room Temperature
pka: 13.51±0.10(Predicted)
form: crystalline powder
color: Faint/pale lemon/gold
InChI: InChI=1S/C8H6FNO/c9-8-3-6(4-10)1-2-7(8)5-11/h1-3,11H,5H2
InChIKey: YGAURRAHPYQHDC-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(CO)C(F)=C1

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
WGK Germany: 1
HS Code: 2926907090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Dam. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735280
Product name: 3-Fluoro-4-(hydroxymethyl)benzonitrile
Purity: 97%
Packaging: 1g
Price: $134.9
Updated: 2025/07/31

TRC

Product number: B435335
Product name: 3-Fluoro-4-(hydroxymethyl)benzonitrile
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: PC500665
Product name: 3-Fluoro-4-(hydroxymethyl)benzonitrile
Purity: 99+%
Packaging: 250mg
Price: $29
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-1U
Product name: 3-Fluoro-4-(hydroxymethyl)benzonitrile
Purity: 99.0%
Packaging: 250mg
Price: $32
Updated: 2021/12/16

ChemScene

Product number: CS-W001260
Product name: 3-fluoro-4-(hydroxymethyl)benzonitrile
Purity: 99.94%
Packaging: 5g
Price: $52
Updated: 2021/12/16

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4-Cyano-2-fluorobenzyl alcohol Chemical Properties,Usage,Production

Uses

4-Cyano-2-fluorobenzyl alcohol is an essential drug intermediate and is widely applied to the synthesis of various drugs. For example: S1P1 Receptor agonists, drugs for treating Alzheimer's disease BMS708163, amides for treating arrhythmia, etc.

Synthesis

4-Cyano-2-fluorobenzyl alcohol, also known as 3-fluoro-4-hydroxymethylbenzonitrile, can be obtained by the reaction of 2-fluoro-4-bromobenzyl alcohol with zinc cyanide or by reduction of 4-cyano-2-fluorobenzoic acid methyl ester.

To a solution of 2-fluoro-4-bromobenzenemethanol (3.25 g, 15.85 mmol) in DMF (35 mL) was added zinc cyanide (1.85 g, 15.85 mmol), tetrakis(triphenylphosphine)palladium (Pd(PPh3) 4.0.916 g, 0.79 mmol), and the reaction was heated with argon deoxygenation for 16 hr. at 100 degrees C., cooled to Room temperature, diluted with ethyl acetate (100mL), washed by water (100mL??3), saturated brine (100mL??3), dried with anhydrous sodium sulfate and filtered, concentrated to crude, then purified by column chromatography (petroleum ether ~ ethyl acetate = 15/1 ~ 4/1 system elution) to obtain a white solid product (0.72g, yield 30%).

4-Cyano-2-fluorobenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Cyano-2-fluorobenzyl alcohol Suppliers

China 155 Europe 1 Germany 1 India 3 United Kingdom 2 United States 7 Global 169

Hangzhou Copiore Chemical Co., Ltd.

Tel: 0571-56501939;0571-56076030 13757145729
Fax: 0571-56501939
Email: sales@copiore.com
Country: China
ProdList: 296
Advantage: 58

Shanghai Jiyu Medical Technology Co., Ltd

Tel: 02161739128 13816953660
Email: wzy@shjypharm.com
Country: China
ProdList: 124
Advantage: 58

Anhui Jianzhu Biotechnology Co., Ltd.

Tel: 15855184105
Email: 3150278607@qq.com
Country: China
ProdList: 64
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 510
Advantage: 57

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11034
Advantage: 64

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View Lastest Price from 4-Cyano-2-fluorobenzyl alcohol manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Cyano-2-fluorobenzyl alcohol 219873-06-0
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

PNP Biotech Co. Ltd

Product: 4-Cyano-2-fluorobenzyl alcohol 219873-06-0
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

Career Henan Chemical Co

Product: 4-Cyano-2-fluorobenzyl alcohol 219873-06-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

219873-06-0, 4-Cyano-2-fluorobenzyl alcoholRelated Search:

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3-Fluoro-4-(hydroxymethyl)benzonitrile

Benzonitrile, 3-fluoro-4-(hydroxymethyl)- (9CI)

4-Cyano-2-fluorobenzyl alcohol

3-Fluoro-4-(hydroxyMethyl)-benzonitrile[4-cyano--2-fluorobenzyl alcohol

3-Fluoro-4-(hydroxymethyl)benzonitrile99+%

Benzonitrile, 3-fluoro-4-(hydroxymethyl)-

3-Fluoro-4-(hydroxymethyl)benzonitrile 97%

4-Cyano-2-fluorobenzyl alcohol ISO 9001：2015 REACH

4-hydroxymethyl-3-fluorobenzonitrile

2-fluoro-4-cyanobenzyl alcohol

3-Fluoro-4-(Hydroxymethyl) Benzonitrile [FHMBN]

4-Cyano-2-florobenzyl alcohol

219873-06-0

219873-06-3

HALIDE

ALDEHYDE