BENDROFLUMETHIAZIDE
- Product Name
- BENDROFLUMETHIAZIDE
- CAS No.
- 73-48-3
- Chemical Name
- BENDROFLUMETHIAZIDE
- Synonyms
- ft8;bhft;ft81;relan;urlea;blh368;centyl;nikion;orsile;pluryl
- CBNumber
- CB3233276
- Molecular Formula
- C15H14F3N3O4S2
- Formula Weight
- 421.41
- MOL File
- 73-48-3.mol
BENDROFLUMETHIAZIDE Property
- Melting point:
- 205-207°C
- Boiling point:
- 602.1±65.0 °C(Predicted)
- Density
- 1.4711 (estimate)
- storage temp.
- Refrigerator
- solubility
- Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent).
- pka
- pKa 8.53±0.05(H2O t=25 I=0.2) (Uncertain)
- color
- Crystals from MeOH/CHCl3
- Water Solubility
- 40mg/L(room temperature)
- EPA Substance Registry System
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide (73-48-3)
Safety
- WGK Germany
- 2
- RTECS
- DK8225000
- HS Code
- 2935904000
- Hazardous Substances Data
- 73-48-3(Hazardous Substances Data)
- Toxicity
- LD50 oral in mouse: > 10gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP967
- Product name
- Bendroflumethiazide
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $233
- Updated
- 2024/03/01
- Product number
- B5775
- Product name
- Bendroflumethiazide
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $58.5
- Updated
- 2024/03/01
- Product number
- 1049000
- Product name
- Bendroflumethiazide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 21311
- Product name
- Bendroflumethiazide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21311
- Product name
- Bendroflumethiazide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
BENDROFLUMETHIAZIDE Chemical Properties,Usage,Production
Description
Bendroflumethiazide (Item No. 21311) is an analytical reference standard categorized as a diuretic. Diuretics, including bendroflumethiazide, have been abused as performance-enhancing drugs and masking agents in sports doping. This product is intended for research and forensic applications.
Chemical Properties
White Solid
Originator
Naturetin,Squibb,US,1959
Uses
Bendroflumethiazide may be used for the same indications as the aforementioned drugs; however, it is primarily used as an adjuvant agent for relieving edema associated with cardiac insufficiency, liver cirrhosis, and edema caused by taking corticosteroids.
Uses
expectorant
Uses
Diuretic; antihypertensive.
Definition
ChEBI: A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Manufacturing Process
The process is described in US Patent 3,392,168 as follows:
(A) Preparation of 5-Trifluoromethylaniline-2,4-Disulfonylchloride - 113 ml of
chlorosulfonic acid is cooled in an ice bath, and to the acid is added dropwise
while stirring 26.6 grams of α,α,α-trifluoro-m-toluidine. 105 grams of sodium
chloride is added during 1-2 hours, where after the temperature of the
reaction mixture is raised slowly to 150° - 160°C which temperature is
maintained for three hours. After cooling the mixture, ice-cooled water is
added, whereby 5-trifluoromethylaniline-2,4-disulfonyl chloride separates out
from the mixture.
(B) Preparation of 5-Trifluoromethyl-2,4-Disulfamylaniline - The 5-
trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (A) is taken up
in ether and the ether solution dried with magnesium sulfate. The ether is
removed from the solution by distillation, the residue is cooled to 0°, and 60
ml of ice-cooled, concentrated ammonia water is added while stirring. The
solution is then heated for one hour on a steam bath and evaporated in vacuo
to crystallization. The crystallized product is 5-trifluoromethyl-2,4-
disulfamylaniline, which is filtered off, washed with water and dried in a
vacuum-desiccator over phosphorus pentoxide. After recrystallization from a
mixture of 30% ethanol and 70% water, the compound has a MP of 247°-
248°C.
(C) Preparation of 3-Benzyl-6-Trifluoromethyl-7-Sulfarnyl-3,4-Dihydro-1,2,4-
Benzothiadiazine-1,1-Dioxide - 6.4 grams of 5-trifluoromethyl-2,4-
disulfamylaniline is dissolved in 12 ml of dioxane, 2.7 ml of
phenylacetaldehyde and a catalytic amount of p-toluenesulfonic acid are
added. After boiling for a short time under reflux, the reaction mixture
crystallizes, and, after filtration and recrystallization from dioxane, the desired product is obtained with a MP of 224.5°-225.5°C.
(D) Alternative to (C) - 9.6 grams of 5-trifluoromethyl-2,4-disulfarnylaniline
and 4.9 grams of ω-ethoxystyrene are dissolved in 35 ml of n-butanol. 0.5
grams of p-toluenesulfonic acid is added, and the mixture is heated on a
steam bath while stirring. When the solution is clear, 55 ml of hexane is
added, whereafter the mixture is heated further for one and a half hours.
After cooling, the substance identical to that of Example (C) is filtered off and
has a MP of 222°-223°C.
Sterile compositions containing Bendroflumethiazide for parenteral
administration may be prepared as described in US Patent 3,265,573.
brand name
Naturetin (Apothecon).
Therapeutic Function
Diuretic, Antihypertensive
Clinical Use
Thiazide diuretic:
Hypertension
Oedema
Safety Profile
Poison by intravenous route.Human systemic effects by ingestion: convulsions andsomnolence. Mutation data reported. When heated todecomposition it emits toxic fumes of F-, SOx, and NOx.
Synthesis
Bendroflumethiazide, 1,1-dioxide 3-benzyl-6-(trifluoromethyl)- 3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.6), is synthesized by the same scheme of making the aforementioned drugs using phenylacetaldehyde or its acetale as a carbonyl component, and using 2,4-disulfonamido-5-trifluoromethylaniline (21.3.5) as an o-aminosulfonamide component.
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with
NSAIDs; antagonism of diuretic effect.
Anti-arrhythmics: hypokalaemia leads to increased
cardiac toxicity; effects of lidocaine and mexiletine
antagonised.
Antibacterials: avoid administration with
lymecycline.
Antidepressants: increased risk of hypokalaemia
with reboxetine; enhanced hypotensive effect with
MAOIs; increased risk of postural hypotension with
tricyclics.
Antiepileptics: increased risk of hyponatraemia with
carbamazepine.
Antifungals: increased risk of hypokalaemia with
amphotericin.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia
increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk
of ventricular arrhythmias with amisulpride;
enhanced hypotensive effect with phenothiazines;
hypokalaemia increases risk of ventricular
arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of
ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: increased risk of nephrotoxicity and
hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium excretion reduced, increased toxicity.
Metabolism
There are indications that bendroflumethiazide is fairly extensively metabolised. About 30% is excreted unchanged in the urine with the remainder excreted as uncharacterised metabolites.
BENDROFLUMETHIAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BENDROFLUMETHIAZIDE manufacturers
- Product
- BENDROFLUMETHIAZIDE 73-48-3
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-11
- Product
- BENDROFLUMETHIAZIDE 73-48-3
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21