Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

Product Name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
CAS No.: 156046-05-8
Chemical Name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
Synonyms: HCl*Dfp-OMe;(S)-methyl 4,4-difluoropyrrolidine-2-carboxylate HCl;(2S)-4,4-difluoro-L-proline methyl ester hydrochloride;L-Proline, 4,4-difluoro-, methyl ester, hydrochloride (1:1);Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride;(S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate hydrochloride;methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
CBNumber: CB72704712
Molecular Formula: C6H10ClF2NO2
Formula Weight: 201.5989064
MOL File: 156046-05-8.mol

More

Less

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid
optical activity: -10.9° (C=0.01 g/ml, H2O)

More

Less

Safety

HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Apolloscientific

Product number: PC201152
Product name: (S)-Methyl4,4-difluoropyrrolidine-2-carboxylatehydrochloride
Purity: 95+%
Packaging: 250mg
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-7-S0
Product name: Methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Apolloscientific

Product number: PC201152
Product name: (S)-Methyl4,4-difluoropyrrolidine-2-carboxylatehydrochloride
Purity: 95+%
Packaging: 1g
Price: $212
Updated: 2021/12/16

Activate Scientific

Product number: AS56468-B-2S
Product name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate HCl
Purity: 97+% ee
Packaging: 1g
Price: $247
Updated: 2021/12/16

Matrix Scientific

Product number: 122649
Product name: Methyl(S)-4,4-difluoropyrrolidine-2-carboxylatehydrochloride
Purity: 97.0%
Packaging: 1g
Price: $364
Updated: 2021/12/16

More

Less

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production

Synthesis

203866-17-5

156046-05-8

General procedure for the synthesis of (S)-4,4-difluoropyrrolidine-2-carboxylic acid methyl ester hydrochloride from N-BOC-4,4-difluoro-L-proline methyl ester: N-BOC-4,4-difluoro-L-proline methyl ester (3 g, 11.3 mmol) was mixed with EtOAc solution (15 mL) of 4 M HCl and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was concentrated in vacuum to afford methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride (2.27 g, 100% yield) as a white solid. The structure of the compound was confirmed by the following spectral data: MS-ESI: m/z 166.14 [M + H]+; 1H NMR (400 MHz, CDCl3): δ 4.70-4.69 (m, 1H), 3.75-3.87 (m, 2H), 3.71 (s, 3H), 2.91-3.00 (m, 1H), 2.70-2.81 (m, 1H).

References

[1] Patent: EP2730572, 2015, B1. Location in patent: Paragraph 0416; 0421

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Suppliers

China 37 India 1 United States 5 Global 43

Shanghai AQBioPharma Co., Ltd.

Tel: 13661411401
Fax: 51370935-8011
Email: yinglv.que@aqbiopharma.com.cn
Country: China
ProdList: 2930
Advantage: 58

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 694
Advantage: 55

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9998
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Nanjing Easichem Co. ltd.

Tel: 18061688856
Email: easichem@126.com
Country: China
ProdList: 477
Advantage: 58

Hefei Molake Biotechnology Co., Ltd.

Tel: 0551-66336380 18956014586
Fax: 055166336380
Email: 983438788@qq.com
Country: China
ProdList: 2297
Advantage: 58

Shanghai Xinxin Pharmaceutical Technology Co., Ltd.

Tel: 13671725141
Email: hickle@yeah.net
Country: China
ProdList: 769
Advantage: 58

BTC Nantong Pharmaceuticals Technology Co.,Ltd

Tel: +8618068193575
Email: sales4@btcpharm.com
Country: China
ProdList: 251
Advantage: 58

156046-05-8, Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochlorideRelated Search:

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

(S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate hydrochloride

(S)-methyl 4,4-difluoropyrrolidine-2-carboxylate HCl

L-Proline, 4,4-difluoro-, methyl ester, hydrochloride (1:1)

HCl*Dfp-OMe

(2S)-4,4-difluoro-L-proline methyl ester hydrochloride

156046-05-8

C6H10ClF2NO2