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CH5138303

Product Name
CH5138303
CAS No.
959763-06-5
Chemical Name
CH5138303
Synonyms
CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
CBNumber
CB72706190
Molecular Formula
C19H18ClN5O2S
Formula Weight
415.9
MOL File
959763-06-5.mol
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CH5138303 Property

Boiling point:
813.1±75.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form 
solid
pka
16.39±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22417
Product name
CH5138303
Purity
≥99%
Packaging
1mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
22417
Product name
CH5138303
Purity
≥99%
Packaging
5mg
Price
$404
Updated
2024/03/01
ApexBio Technology
Product number
B4571
Product name
CH5138303
Packaging
1mg
Price
$67
Updated
2021/12/16
AK Scientific
Product number
2164AH
Product name
4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
Packaging
1mg
Price
$228
Updated
2021/12/16
ApexBio Technology
Product number
B4571
Product name
CH5138303
Packaging
5mg
Price
$237
Updated
2021/12/16
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CH5138303 Chemical Properties,Usage,Production

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.

target

Hsp90

References

[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.

CH5138303 Preparation Products And Raw materials

Raw materials

Preparation Products

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CH5138303 Suppliers

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959763-06-5, CH5138303Related Search:

BIIB-021 Panobinostat 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide NVP-HSP990(HSP990) Luminespib 17-AAG

  • CH5138303
  • Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-
  • CH5138303_Hsp90
  • 4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
  • 4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide
  • 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid
  • 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide
  • CH5138303 USP/EP/BP
  • CH5138303cas
  • 959763-06-5
  • Inhibitors