ChemicalBook > CAS DataBase List > CH5138303

CH5138303

Product Name: CH5138303
CAS No.: 959763-06-5
Chemical Name: CH5138303
Synonyms: CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
CBNumber: CB72706190
Molecular Formula: C19H18ClN5O2S
Formula Weight: 415.9
MOL File: 959763-06-5.mol

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CH5138303 Property

Boiling point:: 813.1±75.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form: solid
pka: 16.39±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22417
Product name: CH5138303
Purity: ≥99%
Packaging: 1mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 22417
Product name: CH5138303
Purity: ≥99%
Packaging: 5mg
Price: $404
Updated: 2024/03/01

ApexBio Technology

Product number: B4571
Product name: CH5138303
Packaging: 1mg
Price: $67
Updated: 2021/12/16

AK Scientific

Product number: 2164AH
Product name: 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
Packaging: 1mg
Price: $228
Updated: 2021/12/16

ApexBio Technology

Product number: B4571
Product name: CH5138303
Packaging: 5mg
Price: $237
Updated: 2021/12/16

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CH5138303 Chemical Properties,Usage,Production

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (K_d = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC₅₀s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED₅₀ = 3.9 mg/kg) and displays high oral bioavailability in mice.

Uses

CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC50 values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model[1][2].

in vivo

CH5138303 (SCID mice bearing NCI-N87 cells, 0-50 mg/kg, Orally, once daily for 11 days) shows potent antitumor efficacy with TGI (tumor growth inhibition) of 136% and a median effective dose (ED₅₀) of 3.9 mg/kg without significant loss of body weight^[1].

target

Hsp90

IC 50

HSP90α: 0.52 nM (Kd)

References

[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.

CH5138303 Preparation Products And Raw materials

Raw materials

Preparation Products

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959763-06-5, CH5138303Related Search:

BIIB-021 Panobinostat 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide NVP-HSP990(HSP990) Luminespib 17-AAG

CH5138303

Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-

CH5138303_Hsp90

4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide

4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide

4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid

4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide

CH5138303 USP/EP/BP

CH5138303cas

959763-06-5

Inhibitors