2-(4-Isopropylpheny)-4H-chroMen-4-one

ChemicalBook > CAS DataBase List > 2-(4-Isopropylpheny)-4H-chroMen-4-one

2-(4-Isopropylpheny)-4H-chroMen-4-one

Product Name: 2-(4-Isopropylpheny)-4H-chroMen-4-one
CAS No.: 92831-11-3
Chemical Name: 2-(4-Isopropylpheny)-4H-chroMen-4-one
Synonyms: MN-64;MN64, >98%;MN64; MN 64;2-(4-Propan-2-ylphenyl)chromen-4-one;2-(4-Isopropyl-phenyl)-chromen-4-one;2-(4-Isopropylpheny)-4H-chroMen-4-one;2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-;MN-64,MN 64,poly ADP ribose polymerase,Inhibitor,PARP,inhibit;2-(4-Isopropyl pheny)-4H-chromen-4-one,(flavone, LXR agonist)
CBNumber: CB72719624
Molecular Formula: C18H16O2
Formula Weight: 264.32
MOL File: 92831-11-3.mol

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2-(4-Isopropylpheny)-4H-chroMen-4-one Property

Melting point:: 63-64 °C(Solv: ethanol (64-17-5))
Boiling point:: 389.8±42.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1012
Product name: MN-64
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1012
Product name: MN-64
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $423
Updated: 2022/05/15

Cayman Chemical

Product number: 17635
Product name: MN-64
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17635
Product name: MN-64
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17635
Product name: MN-64
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

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2-(4-Isopropylpheny)-4H-chroMen-4-one Chemical Properties,Usage,Production

Uses

2-[4-(1-Methylethyl)phenyl4H-1-benzopyran-4-one is a potent and selective tankyrase (TNKS) inhibitor affecting cell proliferation with potential treatment for cancers. Flavonoid compound with anti-cancer/ anti-bacterial properties.

Biological Activity

mn-64 is a type of flavone that act as a potent and selective tankyrase inhibitor (ic50 = 6 and 72 nm for tnks1 and tnks2, respectively). [1]tankytase (tnks) is a member of poly adp ribose polymerases (parps). there are two related homologue, tnks1 and tnks2 that are mostly located in the nuclear pore, cytoplasm, mitotic centrosomes and the golgi apparatus. they involve in cellular functions such as regulation of cell proliferation and promoting telomere elongation in human cells. [1]during an assay for screening flavone tnks inhibitors, mn-64 is discovered for abrogating stf luciferase activity at 200nm and potently inhibiting tnks1 with ic50 of 6nm. it also selectively inhibits tnks1 and tnks2 without affecting any other parps. moreover, mn-64 is prominently more selective than other tnks inhibitors such as xav939. [1]

Biochem/physiol Actions

MN-64 is a very potent inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). The compound MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system.

References

1. narwal m, koivunen j, haikarainen t et al. discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. j med chem. 2013 oct 24;56(20):7880-9.

2-(4-Isopropylpheny)-4H-chroMen-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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92831-11-3, 2-(4-Isopropylpheny)-4H-chroMen-4-oneRelated Search:

MM-102

MN-64

2-(4-Propan-2-ylphenyl)chromen-4-one

2-(4-Isopropylpheny)-4H-chroMen-4-one

2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

MN64; MN 64

2-(4-Isopropyl-phenyl)-chromen-4-one

MN64, >98%

4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-

2-(4-Isopropyl pheny)-4H-chromen-4-one,(flavone, LXR agonist)

MN-64,MN 64,poly ADP ribose polymerase,Inhibitor,PARP,inhibit

92831-11-3