ChemicalBook > CAS DataBase List > 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

Product Name
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
CAS No.
1240948-72-4
Chemical Name
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Synonyms
Vonoprazan-3;Vonoprazan-024;TAK438 Impurity 32;Vonolazan impurity 3;Vonoprazan Impurity Ⅶ;Vonoprazan Impurity 33;TAK438 Intermediate 3;Vonoprazan Fumarate impurity G;Voronozan initiator 1 impurity I;2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
CBNumber
CB72722688
Molecular Formula
C11H6ClFN2
Formula Weight
220.63
MOL File
1240948-72-4.mol
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Property

Boiling point:
403.0±45.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.88±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chemenu
Product number
CM198987
Product name
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Purity
95%
Packaging
1g
Price
$580
Updated
2021/12/16
Crysdot
Product number
CD11318402
Product name
2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Purity
95+%
Packaging
1g
Price
$620
Updated
2021/12/16
Alichem
Product number
1240948724
Product name
2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Packaging
1g
Price
$653
Updated
2021/12/16
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Chemical Properties,Usage,Production

Description

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.

Uses

2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.

Synthesis

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:
2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1240948-72-4, 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrileRelated Search:

Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol 4-Pyridinesulphonic acid 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- PYRIDINE-4-SULFONYL CHLORIDE PYRIDINE-2-SULFONIC ACID 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile 1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate 5-chloropyridine-3-sulfonyl chloride 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

  • 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
  • 1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)-
  • Vonoprazan Fumarate impurity G
  • Vonoprazan Impurity 33
  • Vonoprazan Impurity Ⅶ
  • Vonoprazan-024
  • TAK438 Impurity 32
  • Vonoprazan impurity 28/2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
  • Vonoprazan impurity SM2-A: 2-chloro-5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile
  • Vonoprazan-3
  • Voronozan initiator 1 impurity I
  • 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity）
  • TAK438 Intermediate 3
  • Vonolazan impurity 3
  • 1240948-72-4
  • 1240948-72-4