ChemicalBook > CAS DataBase List > 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid

Product Name
2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid
CAS No.
1211443-58-1
Chemical Name
2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid
Synonyms
Ribociclib Intermediate 1;2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d];2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxy...;2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid;7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid, 2-chloro-7-cyclopentyl-
CBNumber
CB72729571
Molecular Formula
C12H12ClN3O2
Formula Weight
265.7
MOL File
1211443-58-1.mol
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2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid Property

Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
3.63±0.30(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C12H12ClN3O2/c13-12-14-6-7-5-9(11(17)18)16(10(7)15-12)8-3-1-2-4-8/h5-6,8H,1-4H2,(H,17,18)
InChIKey
LXCZVGKSFJMLRO-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C2C=C(C(O)=O)N(C3CCCC3)C2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C587358
Product name
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C587358
Product name
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylicAcid
Packaging
500mg
Price
$155
Updated
2021/12/16
Matrix Scientific
Product number
153521
Product name
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
Purity
95%
Packaging
1g
Price
$79
Updated
2021/12/16
AK Scientific
Product number
9954DN
Product name
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylicacid
Packaging
100mg
Price
$91
Updated
2021/12/16
Matrix Scientific
Product number
153521
Product name
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
Purity
95%
Packaging
5g
Price
$277
Updated
2021/12/16
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2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid Chemical Properties,Usage,Production

Synthesis

1211443-55-8

1211443-58-1

2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxaldehyde (2.69 g, 11 mmol) was used as starting material and dissolved in DMF. Subsequently, Oxone (7.2 g, 12 mmol) was added to this solution and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, water was added to the reaction mixture to precipitate the target product. The yellow solid, 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (2.69 g, 85% yield) was collected by filtration. Mass spectrum (ESI) m/z 266 [M + H]+.

References

[1] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 91

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid Suppliers

China 143 India 4 United States 3 Global 150
Synthonix Inc
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United States
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6872
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Combi-Blocks Inc.
Tel
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sales@combi-blocks.com
Country
United States
ProdList
6618
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Matrix Scientific
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sales@matrixscientific.com
Country
United States
ProdList
6632
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View Lastest Price from 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid manufacturers

Career Henan Chemical Co
Product
2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid 1211443-58-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
100KG
Release date
2018-08-20

1211443-58-1, 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acidRelated Search:

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  • Ribociclib Intermediate 1
  • 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid, 2-chloro-7-cyclopentyl-
  • 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxy...
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  • 1211443-58-1