2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Product Name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS No.: 1211443-61-6
Chemical Name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Synonyms: 2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxaMide;EOS-60967;Ribociclib-1;RIBOCICLIB INT;RIBOCICLIB INT3;(Chloro Amide Impurity);Ribociclib Intermediate 3;Ribociclib Intermediate 4;Ribociclib Chloro Amide IMP;Ribociclib Chloro Amide Impurity
CBNumber: CB02715506
Molecular Formula: C14H17ClN4O
Formula Weight: 292.76
MOL File: 1211443-61-6.mol

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2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Property

Density: 1.40±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid:particulate/powder
pka: 2.78±0.30(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C14H17ClN4O/c1-18(2)13(20)11-7-9-8-16-14(15)17-12(9)19(11)10-5-3-4-6-10/h7-8,10H,3-6H2,1-2H3
InChIKey: PMDDQOHZLBZUSO-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1
LogP: 2.4 at 20℃ and pH7
CAS DataBase Reference: 1211443-61-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C587388
Product name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Packaging: 100mg
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0621042
Product name: 2-CHLORO-7-CYCLOPENTYL-N,N-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $457.73
Updated: 2021/12/16

AK Scientific

Product number: 2802AQ
Product name: 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Packaging: 5g
Price: $1708.4
Updated: 2021/12/16

Chemenu

Product number: CM103621
Product name: 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity: 97%
Packaging: 25g
Price: $495
Updated: 2021/12/16

Ambeed

Product number: A202610
Product name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity: 95%
Packaging: 25g
Price: $311
Updated: 2021/12/16

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2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Chemical Properties,Usage,Production

Uses

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide belongs to pyrimidine derivatives,it is used in the synthesis of ribociclib intermediates.

Synthesis

1211443-58-1

124-40-3

1211443-61-6

To a three-necked flask was added 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid (26.57 g, 100 mmol) and N,N-dimethylformamide (133 mL), and the mixture was cooled to 0-5 °C under stirring. EDCI (23.00 g, 120 mmol) and a tetrahydrofuran solution of dimethylamine (2.0 M, 75 mL, 150 mmol) were then added. Triethylamine (20.24 g, 200 mmol) was added dropwise and the mixture was stirred at 20-25 °C for 6-8 hours. After completion of the reaction, the reaction mixture was extracted three times with ethyl acetate (133 mL) and the organic phases were combined. The organic phase was sequentially washed twice with water and once with brine (133 mL), dried with anhydrous sodium sulfate and concentrated. Finally, the target product 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (26.93 g, 92% yield) was purified by column chromatography in a mixed solvent of dichloromethane and methanol.

References

[1] Patent: CN106478641, 2017, A. Location in patent: Paragraph 0050; 0051; 0052
[2] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 89; 91

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Suppliers

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View Lastest Price from 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-28

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-27

1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamideRelated Search:

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