ChemicalBook > CAS DataBase List > 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Product Name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS No.: 1211443-61-6
Chemical Name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Synonyms: 2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxaMide;EOS-60967;Ribociclib-1;RIBOCICLIB INT;RIBOCICLIB INT3;(Chloro Amide Impurity);Ribociclib Intermediate 3;Ribociclib Intermediate 4;Ribociclib Chloro Amide IMP;Ribociclib Chloro Amide Impurity
CBNumber: CB02715506
Molecular Formula: C14H17ClN4O
Formula Weight: 292.76
MOL File: 1211443-61-6.mol

Less

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Property

Density: 1.40±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid:particulate/powder
pka: 2.78±0.30(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C14H17ClN4O/c1-18(2)13(20)11-7-9-8-16-14(15)17-12(9)19(11)10-5-3-4-6-10/h7-8,10H,3-6H2,1-2H3
InChIKey: PMDDQOHZLBZUSO-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1
LogP: 2.4 at 20℃ and pH7
CAS DataBase Reference: 1211443-61-6

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

TRC

Product number: C587388
Product name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Packaging: 100mg
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0621042
Product name: 2-CHLORO-7-CYCLOPENTYL-N,N-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $457.73
Updated: 2021/12/16

AK Scientific

Product number: 2802AQ
Product name: 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Packaging: 5g
Price: $1708.4
Updated: 2021/12/16

Chemenu

Product number: CM103621
Product name: 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity: 97%
Packaging: 25g
Price: $495
Updated: 2021/12/16

Ambeed

Product number: A202610
Product name: 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity: 95%
Packaging: 25g
Price: $311
Updated: 2021/12/16

Less

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Chemical Properties,Usage,Production

Synthesis

1211443-58-1

124-40-3

1211443-61-6

To a three-necked flask was added 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid (26.57 g, 100 mmol) and N,N-dimethylformamide (133 mL), and the mixture was cooled to 0-5 °C under stirring. EDCI (23.00 g, 120 mmol) and a tetrahydrofuran solution of dimethylamine (2.0 M, 75 mL, 150 mmol) were then added. Triethylamine (20.24 g, 200 mmol) was added dropwise and the mixture was stirred at 20-25 °C for 6-8 hours. After completion of the reaction, the reaction mixture was extracted three times with ethyl acetate (133 mL) and the organic phases were combined. The organic phase was sequentially washed twice with water and once with brine (133 mL), dried with anhydrous sodium sulfate and concentrated. Finally, the target product 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (26.93 g, 92% yield) was purified by column chromatography in a mixed solvent of dichloromethane and methanol.

References

[1] Patent: CN106478641, 2017, A. Location in patent: Paragraph 0050; 0051; 0052
[2] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 89; 91

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Suppliers

China 207 India 6 United States 4 Global 217

Suzhou Carbonwell Pharma-Tech Co., Ltd

Tel: 0512-0512-88981216 13776013740
Email: 1320558046@qq.com
Country: China
ProdList: 72
Advantage: 58

Hangzhou Cheminspire Technology Co., Ltd.

Tel: 0571-89081561; 10006559855
Fax: 0571 89081561
Email: info@cheminspire.com
Country: China
ProdList: 412
Advantage: 58

Jiangsu Yutian pharmaceutical Co.,Ltd.

Tel: 0518-8021621 15062910926
Email: sales@jsytsw.com
Country: China
ProdList: 80
Advantage: 58

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604 13057662806
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 500
Advantage: 65

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Synches Co., Ltd.

Tel: 021-53292253
Fax: 021-53292253
Email: biz@synches.com
Country: China
ProdList: 199
Advantage: 64

Changzhou Joyous Chemical Co., Ltd.

Tel: 0519-85607258 13912342323;
Fax: 0519-85607278
Email: sales@joyouschem.com
Country: China
ProdList: 294
Advantage: 60

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Wuhan Taiyicheng Biopharmaceutical Co., Ltd.

Tel: 027-88320699
Fax: 027-88320962
Email: tycshyy@126.com
Country: China
ProdList: 297
Advantage: 66

China Shenyang Tyschem CO. ,LTD

Tel: +86-024-83607930; 18640359690
Fax: 024-83607930
Email: sales@honghuchem.com
Country: China
ProdList: 256
Advantage: 58

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Suli Pharmaceutical Technology Co., Ltd.

Tel: 021-58086325-8060 13636568474
Fax: 021-51972827
Email: yingjie.zhang@suli.com
Country: China
ProdList: 100
Advantage: 58

Conier Chem & Pharma Co.,Ltd,

Tel: 023-62879767 13996269627;
Fax: +86-28-84559521
Email: sales@conier.com
Country: China
ProdList: 283
Advantage: 56

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Climb Pharmaceutical Technology Co., Ltd.

Tel: 028-87608726 13540107218
Fax: 028-87608725
Email: sales@cdclimb.com
Country: China
ProdList: 104
Advantage: 58

ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd.

Tel: 023-89130144 18523560356
Fax: 023-67534737
Email: zhyong1011@163.com
Country: China
ProdList: 290
Advantage: 58

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.

Tel: +86-18512541987
Fax: 0555-5963572
Email: hll@farmasino.com
Country: China
ProdList: 241
Advantage: 60

Intelligence Pharm Science(Shanghai) Co., Ltd.

Tel: 021-57898186
Fax: 021-37699262
Country: China
ProdList: 449
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
Fax: 021-50275764
Email: Info@rochipharma.com
Country: China
ProdList: 611
Advantage: 55

Fuyang JSK Biomedical Technology Co., Ltd

Tel: 18915409046
Fax: 0510-86566870
Email: 1102409417@qq.com
Country: China
ProdList: 268
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 3495
Advantage: 58

Shanghai Toplab Chemical Co., Ltd.

Tel: 021-31137757-00; 18121466954
Fax: 021-64902762
Email: 28328681@qq.com
Country: China
ProdList: 180
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-50664929, 13971561712
Fax: 027-50664927 / QQ: 3452835437
Email: hubxys2001@163.com
Country: China
ProdList: 1437
Advantage: 55

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9757
Advantage: 58

Adobe Chem Co., Ltd.

Tel: 2332782371
Fax: QQ: 2332782371
Email: adobechem@qq.com
Country: China
ProdList: 7980
Advantage: 58

Suzhou chems bio-tech.co.,Ltd.

Tel: 0512-67903504 13814824891
Fax: QQ604360797
Email: 604360797@qq.com
Country: China
ProdList: 399
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8596
Advantage: 58

Shanghai Elestone Pharmaceutical Technology Co., Ltd.

Tel: 021-36680027/1762825045
Email: sales2@elestone.com.cn
Country: China
ProdList: 296
Advantage: 58

Jinan Daen Pharmaceutical Technology Co., Ltd

Tel: 0531-68657833 15553112864
Fax: -
Email: 2098511187@qq.com
Country: China
ProdList: 295
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 185
Advantage: 58

Less

View Lastest Price from 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-28

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211443-61-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-27

1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamideRelated Search:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid 4-Chloro-5,6-diMethyl-7H-pyrrolo[2,3-d]pyriMidine 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester LEE011 (succinate)

7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-

2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxaMide

7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chlor

RIBOCICLIB INT3

2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide

Ribociclib Chloro Amide IMP

RIBOCICLIB INT

Ribociclib-1

7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide

2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-arboxaMide

2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

EOS-60967

Ribociclib Intermediate 3

Ribociclib Intermediate 4

2-Chloro-7-cyclopentyl-n,n-dimethyl-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide4

Ribociclib Chloro Amide Impurity

2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrol o[2,3-d]pyrimidine-6-carboxamide

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

2-Chloro-7-cyclopentyl-N, Ndimethyl-7H-pyrrolo{2,3-d} pyrimidine-6-carboxylate

2-Chloro-7-cyclopentyl-n,n-dimethyl-7h-pyrrolo[2,3d]pyrimidi...

7H-Pyrrolo[2,3-dChemicalbook]pyriMidine-6-carboxaMide,2-chlor

7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethy

(Chloro Amide Impurity)

2-Chloro-7-cyclopentyl-7H-cyclopentyl[d]pyrimidin-6-carboxamide

1211443-61-6