ChemicalBook > CAS DataBase List > LEE011 (succinate)

LEE011 (succinate)

Product Name
LEE011 (succinate)
CAS No.
1374639-75-4
Chemical Name
LEE011 (succinate)
Synonyms
Ribociclib succinate;RIBOCICLIB SUCCINATE (LEE011);LEE011 (succinate);Ribociclib succite;1374639-75-4 LEE011 (succinate);Ribociclib Succinate (Kisqali);Ribociclib succinate, 10 mM in DMSO;RIBOCICLIB SUCCINATE (LEE011 SUCCINATE);LEE-011 succinate salt, Ribociclib succinate salt;7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
CBNumber
CB92682010
Molecular Formula
C27H36N8O5
Formula Weight
552.64
MOL File
1374639-75-4.mol
More
Less

LEE011 (succinate) Property

Melting point:
>160oC (dec.)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Beige
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

More
Less

N-Bromosuccinimide Price

TRC
Product number
L321000
Product name
LEE011Succinate
Packaging
50mg
Price
$100
Updated
2021/12/16
TRC
Product number
L321000
Product name
LEE011Succinate
Packaging
10mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-2277
Product name
Ribociclibsuccinate
Purity
99.52%
Packaging
10mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-2277
Product name
Ribociclibsuccinate
Purity
99.52%
Packaging
5mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
B1084
Product name
LEE011succinate
Packaging
5mg
Price
$67
Updated
2021/12/16
More
Less

LEE011 (succinate) Chemical Properties,Usage,Production

Uses

LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.

in vivo

CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

IC 50

CDK4: 10 nM (IC50); CDK6: 39 nM (IC50)

LEE011 (succinate) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LEE011 (succinate) Suppliers

China 127 India 6 Israel 1 United States 10 Global 144
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
15502154572
Fax
-
Email
yuben012@sina.com
Country
China
ProdList
484
Advantage
58
Shanghai YiWen Pharmaceutical Co., Ltd.
Tel
13621628489
Email
1322392736@qq.com
Country
China
ProdList
263
Advantage
58
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd
Tel
13732973797; 13732973797
Email
liu@zybiopharma.com
Country
China
ProdList
304
Advantage
58
Shenzhen Yaoyuan R&D Center Co., Ltd
Tel
13421666688 13421666688
Email
664261110@qq.com
Country
China
ProdList
127
Advantage
58
Synches Co., Ltd.
Tel
021-53292253
Fax
021-53292253
Email
biz@synches.com
Country
China
ProdList
199
Advantage
64
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
634
Advantage
58
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
More
Less

View Lastest Price from LEE011 (succinate) manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
LEE011 (succinate) 1374639-75-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-12
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Lee011 (succinate) 1374639-75-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-16
Hebei Senko Biotechnology Co., Ltd.
Product
LEE011 (succinate) 1374639-75-4
Price
US $10.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10 Tons
Release date
2021-08-02

1374639-75-4, LEE011 (succinate)Related Search:

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate LEE011 (hydrochloride) Ribociclib Neratinib Maleate 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

  • LEE011 (succinate)
  • 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
  • LEE-011 succinate salt, Ribociclib succinate salt
  • Ribociclib succinate
  • Ribociclib Succinate (Kisqali)
  • RIBOCICLIB SUCCINATE (LEE011 SUCCINATE)
  • Ribociclib succite
  • RIBOCICLIB SUCCINATE (LEE011)
  • 1374639-75-4 LEE011 (succinate)
  • Ribociclib succinate, 10 mM in DMSO
  • 1374639-75-4
  • C23H30N8OC4H6O4